InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cyp3a13

Summary

InnateDB Gene

IDBG-205564.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp3a13

Gene Name

cytochrome P450, family 3, subfamily a, polypeptide 13

Synonyms

IIIAm2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029727

Encoded Proteins

IDBP-205566

cytochrome P450, family 3, subfamily a, polypeptide 13

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160868:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:137892932-137921619

Strand

Reverse strand

Band

Transcripts

ENSMUST00000031741

ENSMUSP00000031741

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0009822	alkaloid catabolic process
GO:0010628	positive regulation of gene expression
GO:0042737	drug catabolic process
GO:0055114	oxidation-reduction process
GO:0070989	oxidative demethylation