InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP3A4

Summary

InnateDB Gene

IDBG-29569.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP3A4

Gene Name

cytochrome P450, family 3, subfamily A, polypeptide 4

Synonyms

CP33; CP34; CYP3A; CYP3A3; CYPIIIA3; CYPIIIA4; HLP; NF-25; P450C3; P450PCN1

Species

Homo sapiens

Ensembl Gene

ENSG00000160868

Encoded Proteins

IDBP-29571

cytochrome P450, family 3, subfamily A, polypeptide 4

IDBP-29573

cytochrome P450, family 3, subfamily A, polypeptide 4

IDBP-383024

cytochrome P450, family 3, subfamily A, polypeptide 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:99756960-99784265

Strand

Reverse strand

Band

q22.1

Transcripts

ENST00000354593	ENSP00000346607
ENST00000336411	ENSP00000337915
ENST00000415003	ENSP00000397208
ENST00000480043

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	10 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005496	steroid binding
GO:0005506	iron ion binding
GO:0008395	steroid hydroxylase activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825	oxygen binding
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0030343	vitamin D3 25-hydroxylase activity
GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity
GO:0034875	caffeine oxidase activity
GO:0047638	albendazole monooxygenase activity
GO:0050591	quinine 3-monooxygenase activity
GO:0050649	testosterone 6-beta-hydroxylase activity
GO:0070576	vitamin D 24-hydroxylase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006706	steroid catabolic process
GO:0006805	xenobiotic metabolic process
GO:0008202	steroid metabolic process
GO:0008209	androgen metabolic process
GO:0009822	alkaloid catabolic process
GO:0016098	monoterpenoid metabolic process
GO:0017144	drug metabolic process
GO:0036378	calcitriol biosynthetic process from calciol
GO:0042359	vitamin D metabolic process
GO:0042737	drug catabolic process
GO:0042738	exogenous drug catabolic process
GO:0044281	small molecule metabolic process
GO:0046483	heterocycle metabolic process
GO:0055114	oxidation-reduction process
GO:0070989	oxidative demethylation

Cellular Component

GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000029727

View Gene Order

Pathways

NETPATH

REACTOME

REACT_13543

Xenobiotics pathway

REACT_13567

Cytochrome P450 - arranged by substrate type pathway

REACT_228214

Aflatoxin activation and detoxification pathway

REACT_111217

Metabolism pathway

REACT_13433

Biological oxidations pathway

REACT_13705

Phase 1 - Functionalization of compounds pathway

KEGG

hsa00830

Retinol metabolism pathway

hsa00591

Linoleic acid metabolism pathway

hsa00140

Steroid hormone biosynthesis pathway

hsa00980

Metabolism of xenobiotics by cytochrome P450 pathway

hsa00982

Drug metabolism pathway

hsa00983

Drug metabolism pathway

hsa04976

Bile secretion pathway

INOH

INOH website

Tryptophan degradation pathway

PID NCI

Cross-References

SwissProt

P08684

TrEMBL

B4DPQ5 C9JBD2 E7EVM8 Q6GRK0 Q7Z448 Q9BZM0

UniProt Splice Variant

Entrez Gene

1576

UniGene

Hs.728751

RefSeq

NM_001202855 NM_017460

HUGO

HGNC:2637

OMIM

124010

CCDS

CCDS5674

HPRD

IMGT

EMBL

AC069294 AF182273 AF209389 AF280107 AF307089 AJ563376 AK298451 AK312967 BC069418 BC101631 CH236956 CH471091 D00003 DQ005611 DQ924960 J04449 M13785 M14096 M18907 X12387

GenPept

AAA35742 AAA35744 AAA35745 AAA35747 AAF13598 AAF21034 AAG32290 AAG53948 AAH69418 AAI01632 AAY16980 ABI96208 BAA00001 BAG35806 BAG60667 CAA30944 CAD91645 EAL23866 EAW76635

RNA Seq Atlas

1576