InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Crp

Summary

InnateDB Gene

IDBG-205690.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crp

Gene Name

C-reactive protein, pentraxin-related

Synonyms

AI255847

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037942

Encoded Proteins

IDBP-205692

C-reactive protein, pentraxin-related

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21415385

Crp promotes the differentiation of human monocytes toward a pro-inflammatory M1 macrophage phenotype. In addition, Crp treatment of M2 macrophages induced the expression of pro-inflammatory genes and a M1 phenotype. (Demonstrated in human)

InnateDB Annotation from Orthologs

Summary

PMID 16751408

[Homo sapiens] The major acute phase protein in humans that interacts with CFH of the alternative pathway of complement and C4BP of the classical complement pathway, limiting excessive complement activation

PMID 21383176

[Homo sapiens] CRP induces FCAR surface expression, phagocytosis, and TNF secretion in neutrophils. In addition, CRP physically interacts with FCAR, and induces ERK phosphorylation, cytokine production, and degranulation in mast cells.

PMID 21415385

[Homo sapiens] CRP promotes the differentiation of human monocytes toward a pro-inflammatory M1 macrophage phenotype. In addition, CRP treatment of M2 macrophages induced the expression of pro-inflammatory genes and a M1 phenotype.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132693:
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:172698056-172699966

Strand

Forward strand

Band

Transcripts

ENSMUST00000038495

ENSMUSP00000044665

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001849	complement component C1q binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0015485	cholesterol binding
GO:0030169	low-density lipoprotein particle binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0001666	response to hypoxia
GO:0006953	acute-phase response
GO:0006958	complement activation, classical pathway
GO:0007568	aging
GO:0010288	response to lead ion
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010888	negative regulation of lipid storage
GO:0042060	wound healing
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0051258	protein polymerization
GO:0071277	cellular response to calcium ion
GO:1900006	positive regulation of dendrite development