Mus musculus Gene: Crp
Summary
InnateDB Gene IDBG-205690.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Crp
Gene Name C-reactive protein, pentraxin-related
Synonyms AI255847;
Species Mus musculus
Ensembl Gene ENSMUSG00000037942
Encoded Proteins
C-reactive protein, pentraxin-related
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Crp promotes the differentiation of human monocytes toward a pro-inflammatory M1 macrophage phenotype. In addition, Crp treatment of M2 macrophages induced the expression of pro-inflammatory genes and a M1 phenotype. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] The major acute phase protein in humans that interacts with CFH of the alternative pathway of complement and C4BP of the classical complement pathway, limiting excessive complement activation
[Homo sapiens] CRP induces FCAR surface expression, phagocytosis, and TNF secretion in neutrophils. In addition, CRP physically interacts with FCAR, and induces ERK phosphorylation, cytokine production, and degranulation in mast cells.
[Homo sapiens] CRP promotes the differentiation of human monocytes toward a pro-inflammatory M1 macrophage phenotype. In addition, CRP treatment of M2 macrophages induced the expression of pro-inflammatory genes and a M1 phenotype.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132693:
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:172698056-172699966
Strand Forward strand
Band H3
Transcripts
ENSMUST00000038495 ENSMUSP00000044665
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001849 complement component C1q binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0015485 cholesterol binding
GO:0030169 low-density lipoprotein particle binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0001666 response to hypoxia
GO:0006953 acute-phase response
GO:0006958 complement activation, classical pathway
GO:0007568 aging
GO:0010288 response to lead ion
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010888 negative regulation of lipid storage
GO:0042060 wound healing
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0051258 protein polymerization
GO:0071277 cellular response to calcium ion
GO:1900006 positive regulation of dendrite development
Cellular Component
GO:0005615 extracellular space
GO:0030175 filopodium
GO:0030426 growth cone
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Classical antibody-mediated complement activation pathway
Creation of C4 and C2 activators pathway
Complement cascade pathway
Immune System pathway
Initial triggering of complement pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Leptin pathway
REACTOME
Innate Immune System pathway
Classical antibody-mediated complement activation pathway
Creation of C4 and C2 activators pathway
Immune System pathway
Complement cascade pathway
Initial triggering of complement pathway
KEGG
INOH
PID BIOCARTA
PID NCI
IL6-mediated signaling events
Cross-References
SwissProt P14847
TrEMBL
UniProt Splice Variant
Entrez Gene 12944
UniGene Mm.28767
RefSeq NM_007768
OMIM
CCDS CCDS35787
HPRD
IMGT
MGI ID MGI:88512
MGI Symbol Crp
EMBL AC131177 X13588 X17496
GenPept CAA31928 CAA35531
RNA Seq Atlas 12944