Bos taurus Gene: CRP
Summary
InnateDB Gene IDBG-630749.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRP
Gene Name C-reactive protein precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013907
Encoded Proteins
C-reactive protein precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] The major acute phase protein in humans that interacts with CFH of the alternative pathway of complement and C4BP of the classical complement pathway, limiting excessive complement activation
[Homo sapiens] CRP induces FCAR surface expression, phagocytosis, and TNF secretion in neutrophils. In addition, CRP physically interacts with FCAR, and induces ERK phosphorylation, cytokine production, and degranulation in mast cells.
[Homo sapiens] CRP promotes the differentiation of human monocytes toward a pro-inflammatory M1 macrophage phenotype. In addition, CRP treatment of M2 macrophages induced the expression of pro-inflammatory genes and a M1 phenotype.
[Mus musculus] Crp promotes the differentiation of human monocytes toward a pro-inflammatory M1 macrophage phenotype. In addition, Crp treatment of M2 macrophages induced the expression of pro-inflammatory genes and a M1 phenotype. (Demonstrated in human)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132693:
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:10100406-10104524
Strand Forward strand
Band
Transcripts
ENSBTAT00000018469 ENSBTAP00000018469
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001849 complement component C1q binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0030169 low-density lipoprotein particle binding
Biological Process
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010888 negative regulation of lipid storage
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
Leptin pathway
REACTOME
Innate Immune System pathway
Classical antibody-mediated complement activation pathway
Creation of C4 and C2 activators pathway
Immune System pathway
Complement cascade pathway
Initial triggering of complement pathway
Innate Immune System pathway
Classical antibody-mediated complement activation pathway
Creation of C4 and C2 activators pathway
Complement cascade pathway
Immune System pathway
Initial triggering of complement pathway
KEGG
INOH
PID BIOCARTA
PID NCI
IL6-mediated signaling events
Cross-References
SwissProt
TrEMBL C4T8B4
UniProt Splice Variant
Entrez Gene 527553
UniGene Bt.23701
RefSeq NM_001144097
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB255049 DAAA02006995
GenPept BAH66497
RNA Seq Atlas 527553
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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