InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CRP

Summary

InnateDB Gene

IDBG-630749.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRP

Gene Name

C-reactive protein precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013907

Encoded Proteins

IDBP-682224

C-reactive protein precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 16751408

[Homo sapiens] The major acute phase protein in humans that interacts with CFH of the alternative pathway of complement and C4BP of the classical complement pathway, limiting excessive complement activation

PMID 21383176

[Homo sapiens] CRP induces FCAR surface expression, phagocytosis, and TNF secretion in neutrophils. In addition, CRP physically interacts with FCAR, and induces ERK phosphorylation, cytokine production, and degranulation in mast cells.

PMID 21415385

[Homo sapiens] CRP promotes the differentiation of human monocytes toward a pro-inflammatory M1 macrophage phenotype. In addition, CRP treatment of M2 macrophages induced the expression of pro-inflammatory genes and a M1 phenotype.

PMID 21415385

[Mus musculus] Crp promotes the differentiation of human monocytes toward a pro-inflammatory M1 macrophage phenotype. In addition, Crp treatment of M2 macrophages induced the expression of pro-inflammatory genes and a M1 phenotype. (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132693:
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:10100406-10104524

Strand

Forward strand

Band

Transcripts

ENSBTAT00000018469

ENSBTAP00000018469

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001849	complement component C1q binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030169	low-density lipoprotein particle binding