Version 5.4
Mus musculus Gene: Darc
Summary
InnateDB Gene IDBG-205828.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Darc
Gene Name Duffy blood group, chemokine receptor
Synonyms AA162249; CCBP1; CD234; Darc; Dfy; ESTM35; FY; GPD
Species Mus musculus
Ensembl Gene ENSMUSG00000037872
Encoded Proteins
IDBP-205830
Duffy blood group, chemokine receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213088:
The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:173331886-173333503
Strand Reverse strand
Band H3
Transcripts
ENSMUST00000038227 ENSMUSP00000045134
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0019957 C-C chemokine binding
Biological Process
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0032642 regulation of chemokine production
GO:0070098 chemokine-mediated signaling pathway
Cellular Component
GO:0005769 early endosome
GO:0016021 integral component of membrane
GO:0055037 recycling endosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000213088
View Gene Order
ENSBTAG00000003220
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05144
Malaria pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa05144
Malaria pathway
INOH
PID NCI
Cross-References
SwissProt Q9QUI6
TrEMBL
UniProt Splice Variant
Entrez Gene 13349
UniGene Mm.6393
RefSeq NM_010045
OMIM
CCDS CCDS35789
HPRD
IMGT
MGI ID MGI:1097689
MGI Symbol Ackr1
EMBL AB039074 AB039075 AB039076 AB039077 AB039078 AB039079 AB039080 AB039081 AB039082 AF016584 AF016697 AF109159 BC005583 U88431
GenPept AAC53354 AAC53360 AAF08328 AAF14225 AAH05583 BAB68598 BAB68599 BAB68600 BAB68601 BAB68602 BAB68603 BAB68604 BAB68605 BAB68606
RNA Seq Atlas 13349

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca