Version 5.4
Homo sapiens Gene: DARC
Summary
InnateDB Gene IDBG-246055.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DARC
Gene Name Duffy blood group, chemokine receptor
Synonyms CCBP1; CD234; DARC; Dfy; FY; GPD; GpFy; WBCQ1
Species Homo sapiens
Ensembl Gene ENSG00000213088
Encoded Proteins
IDBP-103874
Duffy blood group, chemokine receptor
IDBP-103878
Duffy blood group, chemokine receptor
IDBP-389202
Duffy blood group, chemokine receptor
IDBP-595336
Duffy blood group, chemokine receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:159203307-159206500
Strand Forward strand
Band q23.2
Transcripts
ENST00000368122 ENSP00000357104
ENST00000368121 ENSP00000357103
ENST00000435307 ENSP00000398406
ENST00000537147 ENSP00000441985
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0019956 chemokine binding
GO:0019957 C-C chemokine binding
Biological Process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0032642 regulation of chemokine production
GO:0070098 chemokine-mediated signaling pathway
Cellular Component
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0055037 recycling endosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037872
View Gene Order
ENSBTAG00000003220
Not yet available
Pathways
NETPATH
REACTOME
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa05144
Malaria pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.153381
RefSeq NM_001122951 NM_002036
HUGO
OMIM
CCDS CCDS1183 CCDS44252
HPRD 00192
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca