Homo sapiens Gene: FNTA
Summary
InnateDB Gene IDBG-20616.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FNTA
Gene Name farnesyltransferase, CAAX box, alpha
Synonyms FPTA; PGGT1A; PTAR2;
Species Homo sapiens
Ensembl Gene ENSG00000168522
Encoded Proteins
farnesyltransferase, CAAX box, alpha
farnesyltransferase, CAAX box, alpha
farnesyltransferase, CAAX box, alpha
farnesyltransferase, CAAX box, alpha
farnesyltransferase, CAAX box, alpha
farnesyltransferase, CAAX box, alpha
farnesyltransferase, CAAX box, alpha
farnesyltransferase, CAAX box, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:43034194-43085788
Strand Forward strand
Band p11.21
Transcripts
ENST00000302279 ENSP00000303423
ENST00000533559
ENST00000526755 ENSP00000437208
ENST00000527153
ENST00000533383 ENSP00000435455
ENST00000533998 ENSP00000432892
ENST00000524546
ENST00000531266 ENSP00000432411
ENST00000533368
ENST00000525699 ENSP00000436998
ENST00000529687 ENSP00000473479
ENST00000533336 ENSP00000434430
ENST00000525099
ENST00000528400
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004660 protein farnesyltransferase activity
GO:0004661 protein geranylgeranyltransferase activity
GO:0004662 CAAX-protein geranylgeranyltransferase activity
GO:0004663 Rab geranylgeranyltransferase activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008318 protein prenyltransferase activity
GO:0030548 acetylcholine receptor regulator activity
GO:0030971 receptor tyrosine kinase binding
GO:0043014 alpha-tubulin binding
Biological Process
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007603 phototransduction, visible light
GO:0010469 regulation of receptor activity
GO:0016056 rhodopsin mediated signaling pathway
GO:0018342 protein prenylation
GO:0018343 protein farnesylation
GO:0018344 protein geranylgeranylation
GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0045213 neurotransmitter receptor metabolic process
GO:0090044 positive regulation of tubulin deacetylation
GO:0090045 positive regulation of deacetylase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005875 microtubule associated complex
GO:0005953 CAAX-protein geranylgeranyltransferase complex
GO:0005965 protein farnesyltransferase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
Apoptotic execution phase pathway
Apoptosis pathway
Signal Transduction pathway
Apoptotic cleavage of cellular proteins pathway
Diseases associated with visual transduction pathway
Visual phototransduction pathway
The phototransduction cascade pathway
Inactivation, recovery and regulation of the phototransduction cascade pathway
Disease pathway
KEGG
Terpenoid backbone biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL B3KVN2 E9PPM9
UniProt Splice Variant
Entrez Gene 2339
UniGene
RefSeq NM_002027
HUGO HGNC:3782
OMIM 134635
CCDS CCDS6140
HPRD
IMGT
EMBL AC110275 AC113191 AK123002 CH471080
GenPept BAG53844 EAW63191
RNA Seq Atlas 2339