Homo sapiens Gene: DSG3
Summary
InnateDB Gene IDBG-2065.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DSG3
Gene Name desmoglein 3
Synonyms CDHF6; PVA;
Species Homo sapiens
Ensembl Gene ENSG00000134757
Encoded Proteins
desmoglein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:31447795-31478702
Strand Forward strand
Band q12.1
Transcripts
ENST00000257189 ENSP00000257189
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007156 homophilic cell adhesion
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030057 desmosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Apoptotic execution phase pathway
Apoptosis pathway
Apoptotic cleavage of cell adhesion proteins pathway
Apoptotic cleavage of cellular proteins pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P32926
TrEMBL
UniProt Splice Variant
Entrez Gene 1830
UniGene Hs.1925 Hs.619696
RefSeq NM_001944
HUGO HGNC:3050
OMIM 169615
CCDS CCDS11898
HPRD
IMGT
EMBL AC021549 AK290367 M76482
GenPept AAA60230 BAF83056
RNA Seq Atlas 1830