Version 5.4
Mus musculus Gene: Appbp2
Summary
InnateDB Gene IDBG-206584.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Appbp2
Gene Name amyloid beta precursor protein (cytoplasmic tail) binding protein 2
Synonyms 1300003O07Rik; AI465480; PAT1
Species Mus musculus
Ensembl Gene ENSMUSG00000018481
Encoded Proteins
IDBP-206586
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000062725:
The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. This gene has been found to be highly expressed in breast cancer. Multiple polyadenylation sites have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer\'s disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:85187262-85235130
Strand Reverse strand
Band C
Transcripts
ENSMUST00000018625 ENSMUSP00000018625
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0015031 protein transport
GO:0046907 intracellular transport
Cellular Component
GO:0005634 nucleus
GO:0005874 microtubule
GO:0030659 cytoplasmic vesicle membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000062725
View Gene Order
ENSBTAG00000004489
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt Q9DAX9
TrEMBL
UniProt Splice Variant
Entrez Gene 66884
UniGene Mm.271997 Mm.479225 Mm.479363 Mm.479413 Mm.479498
RefSeq NM_025825
OMIM
CCDS CCDS25193
HPRD
IMGT
MGI ID MGI:1914134
MGI Symbol Appbp2
EMBL AK005440 AK122222 AL596183 BC018442 BC019152
GenPept AAH18442 AAH19152 BAB24034 BAC65504 CAI24920
RNA Seq Atlas 66884

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca