Homo sapiens Gene: APPBP2
Summary
InnateDB Gene IDBG-62307.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APPBP2
Gene Name amyloid beta precursor protein (cytoplasmic tail) binding protein 2
Synonyms APP-BP2; HS.84084; PAT1;
Species Homo sapiens
Ensembl Gene ENSG00000062725
Encoded Proteins
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. This gene has been found to be highly expressed in breast cancer. Multiple polyadenylation sites have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer\'s disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:60443149-60526219
Strand Reverse strand
Band q23.2
Transcripts
ENST00000083182 ENSP00000083182
ENST00000590244
ENST00000592995
ENST00000589341 ENSP00000467025
ENST00000588668 ENSP00000466802
ENST00000585368 ENSP00000464962
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0008152 metabolic process
GO:0046907 intracellular transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0030659 cytoplasmic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL K7ENN3
UniProt Splice Variant
Entrez Gene 10513
UniGene Hs.711594 Hs.84084
RefSeq NM_001282476 NM_006380 XM_006721639
HUGO HGNC:622
OMIM 605324
CCDS CCDS32699
HPRD 05616
IMGT
EMBL AC011921 AC037475
GenPept
RNA Seq Atlas 10513