Mus musculus Gene: Adm
Summary
InnateDB Gene IDBG-206620.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Adm
Gene Name adrenomedullin
Synonyms AM;
Species Mus musculus
Ensembl Gene ENSMUSG00000030790
Encoded Proteins
adrenomedullin
adrenomedullin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148926:
Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:110627661-110629820
Strand Forward strand
Band E3
Transcripts
ENSMUST00000033054 ENSMUSP00000033054
ENSMUST00000186620 ENSMUSP00000140890
ENSMUST00000185766
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0031700 adrenomedullin receptor binding
Biological Process
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001843 neural tube closure
GO:0002026 regulation of the force of heart contraction
GO:0002031 G-protein coupled receptor internalization
GO:0006171 cAMP biosynthetic process
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007507 heart development
GO:0007565 female pregnancy
GO:0007568 aging
GO:0008209 androgen metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009409 response to cold
GO:0009611 response to wounding
GO:0010033 response to organic substance
GO:0010460 positive regulation of heart rate
GO:0019933 cAMP-mediated signaling
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0031100 organ regeneration
GO:0031102 neuron projection regeneration
GO:0031623 receptor internalization
GO:0032496 response to lipopolysaccharide
GO:0032868 response to insulin
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042594 response to starvation
GO:0043065 positive regulation of apoptotic process
GO:0043116 negative regulation of vascular permeability
GO:0045766 positive regulation of angiogenesis
GO:0045906 negative regulation of vasoconstriction
GO:0045909 positive regulation of vasodilation
GO:0046879 hormone secretion
GO:0048589 developmental growth
GO:0051384 response to glucocorticoid
GO:0055074 calcium ion homeostasis
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060712 spongiotrophoblast layer development
GO:0097084 vascular smooth muscle cell development
GO:2001214 positive regulation of vasculogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
GPCR downstream signaling pathway
Signaling by GPCR pathway
Class B/2 (Secretin family receptors) pathway
Calcitonin-like ligand receptors pathway
GPCR ligand binding pathway
Signal Transduction pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
G alpha (s) signalling events pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Calcitonin-like ligand receptors pathway
GPCR ligand binding pathway
Class B/2 (Secretin family receptors) pathway
Signaling by GPCR pathway
G alpha (s) signalling events pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Calcitonin-like ligand receptors pathway
Class B/2 (Secretin family receptors) pathway
KEGG
INOH
PID BIOCARTA
PID NCI
HIF-1-alpha transcription factor network
Cross-References
SwissProt P97297
TrEMBL
UniProt Splice Variant
Entrez Gene 11535
UniGene Mm.1408 Mm.470780
RefSeq NM_009627
OMIM
CCDS CCDS21745
HPRD
IMGT
MGI ID MGI:108058
MGI Symbol Adm
EMBL AK144181 AK144600 AK144649 AK171066 BC052665 CH466531 D78349 U77630
GenPept AAB36535 AAH52665 BAA11367 BAE25751 BAE25959 BAE25989 BAE42225 EDL16987
RNA Seq Atlas 11535