Bos taurus Gene: ADM
Summary
InnateDB Gene IDBG-633364.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADM
Gene Name bta-mir-6518
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021048
Encoded Proteins
ADMAdrenomedullinAdrenomedullin-11-26Proadrenomedullin N-20 terminal peptide
ADMAdrenomedullinAdrenomedullin-11-26Proadrenomedullin N-20 terminal peptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148926:
Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:42911044-42913326
Strand Reverse strand
Band
Transcripts
ENSBTAT00000028036 ENSBTAP00000028036
ENSBTAT00000063482 ENSBTAP00000053999
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
Biological Process
GO:0001570 vasculogenesis
GO:0001843 neural tube closure
GO:0002031 G-protein coupled receptor internalization
GO:0006171 cAMP biosynthetic process
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0031623 receptor internalization
GO:0043116 negative regulation of vascular permeability
GO:0045766 positive regulation of angiogenesis
GO:0045906 negative regulation of vasoconstriction
GO:0048589 developmental growth
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060712 spongiotrophoblast layer development
GO:0097084 vascular smooth muscle cell development
GO:2001214 positive regulation of vasculogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by GPCR pathway
G alpha (s) signalling events pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Calcitonin-like ligand receptors pathway
Class B/2 (Secretin family receptors) pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
G alpha (s) signalling events pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Calcitonin-like ligand receptors pathway
GPCR ligand binding pathway
Class B/2 (Secretin family receptors) pathway
G alpha (s) signalling events pathway
GPCR downstream signaling pathway
Signaling by GPCR pathway
Class B/2 (Secretin family receptors) pathway
Calcitonin-like ligand receptors pathway
GPCR ligand binding pathway
Signal Transduction pathway
KEGG
INOH
PID BIOCARTA
PID NCI
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.2047
RefSeq NM_173888 XM_005215894
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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