Version 5.4
Mus musculus Gene: Chd5
Summary
InnateDB Gene IDBG-206687.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chd5
Gene Name chromodomain helicase DNA binding protein 5
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000005045
Encoded Proteins
IDBP-206689
chromodomain helicase DNA binding protein 5
IDBP-206691
chromodomain helicase DNA binding protein 5
IDBP-624621
chromodomain helicase DNA binding protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116254:
This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:152338651-152390194
Strand Forward strand
Band E2
Transcripts
ENSMUST00000030775 ENSMUSP00000030775
ENSMUST00000005175 ENSMUSP00000005175
ENSMUST00000136134
ENSMUST00000124423
ENSMUST00000164662 ENSMUSP00000132600
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0035064 methylated histone binding
GO:0042826 histone deacetylase binding
GO:0061628 H3K27me3 modified histone binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0008285 negative regulation of cell proliferation
GO:0021895 cerebral cortex neuron differentiation
GO:0035093 spermatogenesis, exchange of chromosomal proteins
GO:0043967 histone H4 acetylation
GO:0045595 regulation of cell differentiation
GO:0060850 regulation of transcription involved in cell fate commitment
GO:0098532 histone H3-K27 trimethylation
GO:1901798 positive regulation of signal transduction by p53 class mediator
Cellular Component
GO:0000785 chromatin
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0016020 membrane
GO:0016581 NuRD complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116254
View Gene Order
ENSBTAG00000040477
Not yet available
Cross-References
SwissProt A2A8L1
TrEMBL
UniProt Splice Variant
Entrez Gene 269610
UniGene Mm.396692 Mm.40192
RefSeq XM_006538931 XM_006538932 NM_001081376 NM_029216 XM_006538929 XM_006538930 XM_006538933 XM_006538934 XM_006538935
OMIM
CCDS CCDS38984 CCDS51394
HPRD
IMGT
MGI ID MGI:3036258
MGI Symbol Chd5
EMBL AK129145 AL611985
GenPept BAC97955
RNA Seq Atlas 269610

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca