InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHD5

Summary

InnateDB Gene

IDBG-87288.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHD5

Gene Name

chromodomain helicase DNA binding protein 5

Synonyms

CHD-5

Species

Homo sapiens

Ensembl Gene

ENSG00000116254

Encoded Proteins

IDBP-87290

chromodomain helicase DNA binding protein 5

IDBP-87300

chromodomain helicase DNA binding protein 5

IDBP-721632

IDBP-721563

IDBP-591022

chromodomain helicase DNA binding protein 5

IDBP-722617

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:6101793-6180123

Strand

Reverse strand

Band

p36.31

Transcripts

ENST00000262450	ENSP00000262450
ENST00000377999	ENSP00000367238
ENST00000475121	ENSP00000466440
ENST00000462991	ENSP00000466706
ENST00000496404	ENSP00000433676
ENST00000491020	ENSP00000468624

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	4 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0061628	H3K27me3 modified histone binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0008152	metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0021895	cerebral cortex neuron differentiation
GO:0035093	spermatogenesis, exchange of chromosomal proteins
GO:0043967	histone H4 acetylation
GO:0060850	regulation of transcription involved in cell fate commitment
GO:0098532	histone H3-K27 trimethylation
GO:1901798	positive regulation of signal transduction by p53 class mediator

Cellular Component

GO:0000785	chromatin
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0016020	membrane
GO:0016581	NuRD complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000005045

View Gene Order

ENSBTAG00000040477

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.522898 Hs.618109

RefSeq

NM_015557

HUGO

OMIM

CCDS

CCDS57

HPRD

10828

IMGT

EMBL

GenPept

RNA Seq Atlas