Homo sapiens Gene: CHD5
Summary
InnateDB Gene IDBG-87288.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHD5
Gene Name chromodomain helicase DNA binding protein 5
Synonyms CHD-5;
Species Homo sapiens
Ensembl Gene ENSG00000116254
Encoded Proteins
chromodomain helicase DNA binding protein 5
chromodomain helicase DNA binding protein 5
chromodomain helicase DNA binding protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:6101793-6180123
Strand Reverse strand
Band p36.31
Transcripts
ENST00000262450 ENSP00000262450
ENST00000377999 ENSP00000367238
ENST00000475121 ENSP00000466440
ENST00000462991 ENSP00000466706
ENST00000496404 ENSP00000433676
ENST00000491020 ENSP00000468624
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 4 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0061628 H3K27me3 modified histone binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0008152 metabolic process
GO:0008285 negative regulation of cell proliferation
GO:0021895 cerebral cortex neuron differentiation
GO:0035093 spermatogenesis, exchange of chromosomal proteins
GO:0043967 histone H4 acetylation
GO:0060850 regulation of transcription involved in cell fate commitment
GO:0098532 histone H3-K27 trimethylation
GO:1901798 positive regulation of signal transduction by p53 class mediator
Cellular Component
GO:0000785 chromatin
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0016020 membrane
GO:0016581 NuRD complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 26038
UniGene Hs.522898 Hs.618109
RefSeq NM_015557
HUGO HGNC:16816
OMIM 610771
CCDS CCDS57
HPRD 10828
IMGT
EMBL
GenPept
RNA Seq Atlas 26038