Mus musculus Gene: Rps6kb1
Summary
InnateDB Gene IDBG-206895.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rps6kb1
Gene Name ribosomal protein S6 kinase, polypeptide 1
Synonyms 2610318I15Rik; 4732464A07Rik; 70kDa; AA959758; AI256796; AI314060; p70/85s6k; p70s6k; S6K1;
Species Mus musculus
Ensembl Gene ENSMUSG00000020516
Encoded Proteins
ribosomal protein S6 kinase, polypeptide 1
ribosomal protein S6 kinase, polypeptide 1
ribosomal protein S6 kinase, polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108443:
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:86498871-86544805
Strand Reverse strand
Band C
Transcripts
ENSMUST00000020824
ENSMUST00000058286 ENSMUSP00000053188
ENSMUST00000154617 ENSMUSP00000119715
ENSMUST00000149392
ENSMUST00000131194
ENSMUST00000151748
ENSMUST00000138810 ENSMUSP00000122756
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 60 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004711 ribosomal protein S6 kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042277 peptide binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0003009 skeletal muscle contraction
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007281 germ cell development
GO:0007568 aging
GO:0007584 response to nutrient
GO:0007616 long-term memory
GO:0009408 response to heat
GO:0009611 response to wounding
GO:0009612 response to mechanical stimulus
GO:0009636 response to toxic substance
GO:0009749 response to glucose
GO:0010033 response to organic substance
GO:0014070 response to organic cyclic compound
GO:0014732 skeletal muscle atrophy
GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016477 cell migration
GO:0031929 TOR signaling
GO:0032496 response to lipopolysaccharide
GO:0032868 response to insulin
GO:0032870 cellular response to hormone stimulus
GO:0033574 response to testosterone
GO:0033762 response to glucagon
GO:0034612 response to tumor necrosis factor
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043200 response to amino acid
GO:0043201 response to leucine
GO:0043434 response to peptide hormone
GO:0043491 protein kinase B signaling
GO:0045471 response to ethanol
GO:0045727 positive regulation of translation
GO:0045931 positive regulation of mitotic cell cycle
GO:0045948 positive regulation of translational initiation
GO:0046324 regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048633 positive regulation of skeletal muscle tissue growth
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051384 response to glucocorticoid
GO:0071363 cellular response to growth factor stimulus
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0009986 cell surface
GO:0030054 cell junction
GO:0043005 neuron projection
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by Insulin receptor pathway
S6K1 signalling pathway
Insulin receptor signalling cascade pathway
S6K1-mediated signalling pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
PI3K Cascade pathway
IRS-related events pathway
IRS-mediated signalling pathway
mTORC1-mediated signalling pathway
Signal Transduction pathway
mTOR signalling pathway
PKB-mediated events pathway
KEGG
ErbB signaling pathway pathway
mTOR signaling pathway pathway
TGF-beta signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Insulin signaling pathway pathway
Acute myeloid leukemia pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL2 pathway
IL4 pathway
IL6 pathway
RANKL pathway
Leptin pathway
TSH pathway
Prolactin pathway
IL11 pathway
REACTOME
PKB-mediated events pathway
mTOR signalling pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
S6K1 signalling pathway
mTORC1-mediated signalling pathway
Signal Transduction pathway
PI3K Cascade pathway
IRS-mediated signalling pathway
S6K1-mediated signalling pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IRS-related events pathway
IGF1R signaling cascade pathway
Signaling by Insulin receptor pathway
Insulin receptor signalling cascade pathway
S6K1-mediated signalling pathway
PKB-mediated events pathway
IRS-related events triggered by IGF1R pathway
mTOR signalling pathway
mTORC1-mediated signalling pathway
IRS-related events pathway
IRS-mediated signalling pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
IGF1R signaling cascade pathway
Signal Transduction pathway
S6K1 signalling pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
KEGG
ErbB signaling pathway pathway
mTOR signaling pathway pathway
TGF-beta signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Insulin signaling pathway pathway
Acute myeloid leukemia pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
PID BIOCARTA
Il-2 receptor beta chain in t cell activation [Biocarta view]
Ctcf: first multivalent nuclear factor [Biocarta view]
Nfat and hypertrophy of the heart [Biocarta view]
Regulation of eif-4e and p70s6 kinase [Biocarta view]
Il 4 signaling pathway [Biocarta view]
Mtor signaling pathway [Biocarta view]
Rac1 cell motility signaling pathway [Biocarta view]
Skeletal muscle hypertrophy is regulated via akt-mtor pathway [Biocarta view]
Phosphoinositides and their downstream targets [Biocarta view]
PID NCI
RXR and RAR heterodimerization with other nuclear receptor
Integrins in angiogenesis
mTOR signaling pathway
a6b1 and a6b4 Integrin signaling
IGF1 pathway
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
IL4-mediated signaling events
CDC42 signaling events
TGF-beta receptor signaling
IL2 signaling events mediated by PI3K
Insulin Pathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.394280 Mm.470750 Mm.486655
RefSeq NM_001114334 NM_028259 XM_006534314 XM_006534315 XM_006534316 XM_006534317 XM_006534318
OMIM
CCDS CCDS25201 CCDS48875
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas