InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPS6KB1

Summary

InnateDB Gene

IDBG-61938.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS6KB1

Gene Name

ribosomal protein S6 kinase, 70kDa, polypeptide 1

Synonyms

p70 S6KA; p70-alpha; p70-S6K; p70(S6K)-alpha; PS6K; S6K; S6K-beta-1; S6K1; STK14A

Species

Homo sapiens

Ensembl Gene

ENSG00000108443

Encoded Proteins

IDBP-61940

ribosomal protein S6 kinase, 70kDa, polypeptide 1

IDBP-244455

ribosomal protein S6 kinase, 70kDa, polypeptide 1

IDBP-294156

ribosomal protein S6 kinase, 70kDa, polypeptide 1

IDBP-587769

ribosomal protein S6 kinase, 70kDa, polypeptide 1

IDBP-764619

IDBP-763809

IDBP-763193

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:59893046-59950564

Strand

Forward strand

Band

q23.1

Transcripts

ENST00000225577	ENSP00000225577
ENST00000393021	ENSP00000376744
ENST00000406116	ENSP00000384335
ENST00000443572	ENSP00000441993
ENST00000472940	ENSP00000468058
ENST00000477179
ENST00000489824	ENSP00000466562
ENST00000475155
ENST00000587061
ENST00000590928
ENST00000587622
ENST00000592726	ENSP00000464805

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	83 [view]
Protein-Protein	79 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004711	ribosomal protein S6 kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042277	peptide binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0003009	skeletal muscle contraction
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007281	germ cell development
GO:0007568	aging
GO:0007584	response to nutrient
GO:0007616	long-term memory
GO:0008286	insulin receptor signaling pathway
GO:0009408	response to heat
GO:0009611	response to wounding
GO:0009612	response to mechanical stimulus
GO:0009636	response to toxic substance
GO:0009749	response to glucose
GO:0010033	response to organic substance
GO:0014070	response to organic cyclic compound
GO:0014732	skeletal muscle atrophy
GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation
GO:0014911	positive regulation of smooth muscle cell migration
GO:0016477	cell migration
GO:0031929	TOR signaling
GO:0032496	response to lipopolysaccharide
GO:0032868	response to insulin
GO:0032870	cellular response to hormone stimulus
GO:0033574	response to testosterone
GO:0033762	response to glucagon
GO:0034612	response to tumor necrosis factor
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043200	response to amino acid
GO:0043201	response to leucine
GO:0043434	response to peptide hormone
GO:0043491	protein kinase B signaling
GO:0045471	response to ethanol
GO:0045727	positive regulation of translation
GO:0045931	positive regulation of mitotic cell cycle
GO:0045948	positive regulation of translational initiation
GO:0046324	regulation of glucose import
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048633	positive regulation of skeletal muscle tissue growth
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051384	response to glucocorticoid
GO:0071363	cellular response to growth factor stimulus
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0009986	cell surface
GO:0030054	cell junction
GO:0043005	neuron projection
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm