InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cdc25b

Summary

InnateDB Gene

IDBG-207014.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdc25b

Gene Name

cell division cycle 25B

Synonyms

AI604853

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027330

Encoded Proteins

IDBP-207016

cell division cycle 25 homolog B (S. pombe)

IDBP-207018

cell division cycle 25 homolog B (S. pombe)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101224:
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:131186949-131198497

Strand

Forward strand

Band

Transcripts

ENSMUST00000028804	ENSMUSP00000028804
ENSMUST00000079857	ENSMUSP00000078784
ENSMUST00000125423
ENSMUST00000132727
ENSMUST00000141732
ENSMUST00000138669
ENSMUST00000145556

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000087	mitotic M phase
GO:0001556	oocyte maturation
GO:0006468	protein phosphorylation
GO:0006470	protein dephosphorylation
GO:0007067	mitotic nuclear division
GO:0007144	female meiosis I
GO:0032467	positive regulation of cytokinesis
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0045860	positive regulation of protein kinase activity
GO:0045931	positive regulation of mitotic cell cycle