Mus musculus Gene: Cdc25b
Summary
InnateDB Gene IDBG-207014.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdc25b
Gene Name cell division cycle 25B
Synonyms AI604853;
Species Mus musculus
Ensembl Gene ENSMUSG00000027330
Encoded Proteins
cell division cycle 25 homolog B (S. pombe)
cell division cycle 25 homolog B (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101224:
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:131186949-131198497
Strand Forward strand
Band F1
Transcripts
ENSMUST00000028804 ENSMUSP00000028804
ENSMUST00000079857 ENSMUSP00000078784
ENSMUST00000125423
ENSMUST00000132727
ENSMUST00000141732
ENSMUST00000138669
ENSMUST00000145556
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000087 mitotic M phase
GO:0001556 oocyte maturation
GO:0006468 protein phosphorylation
GO:0006470 protein dephosphorylation
GO:0007067 mitotic nuclear division
GO:0007144 female meiosis I
GO:0032467 positive regulation of cytokinesis
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0045860 positive regulation of protein kinase activity
GO:0045931 positive regulation of mitotic cell cycle
Cellular Component
GO:0000922 spindle pole
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Cell Cycle pathway
Mitotic G2-G2/M phases pathway
Cyclin A/B1 associated events during G2/M transition pathway
Cyclin B2 mediated events pathway
KEGG
MAPK signaling pathway pathway
Cell cycle pathway
Progesterone-mediated oocyte maturation pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
AndrogenReceptor pathway
REACTOME
Cyclin A/B1 associated events during G2/M transition pathway
S Phase pathway
Cell Cycle pathway
G2/M Transition pathway
Cyclin B2 mediated events pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
KEGG
MAPK signaling pathway pathway
Cell cycle pathway
Progesterone-mediated oocyte maturation pathway
INOH
PID BIOCARTA
PID NCI
Aurora A signaling
FOXM1 transcription factor network
p38 signaling mediated by MAPKAP kinases
PLK1 signaling events
Cross-References
SwissProt
TrEMBL Q9DBN8
UniProt Splice Variant
Entrez Gene 12531
UniGene Mm.38444
RefSeq NM_001111075 NM_023117
OMIM
CCDS CCDS50717 CCDS16758
HPRD
IMGT
MGI ID MGI:99701
MGI Symbol Cdc25b
EMBL AK004836 AK043730 AL808128 AL831736 AL935321 BC057568
GenPept AAH57568 BAB23603 BAC31632
RNA Seq Atlas 12531