InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdc25b

Summary

InnateDB Protein

IDBP-207016.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdc25b

Protein Name

cell division cycle 25 homolog B (S. pombe)

Synonyms

AI604853;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028804

InnateDB Gene

IDBG-207014 (Cdc25b)

Protein Structure

UniProt Annotation

Function

Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed predominantly in spleen, lung, heart, brain, intestine, and muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000087	mitotic M phase
GO:0001556	oocyte maturation
GO:0006468	protein phosphorylation
GO:0006470	protein dephosphorylation
GO:0007067	mitotic nuclear division
GO:0007144	female meiosis I
GO:0032467	positive regulation of cytokinesis
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0045860	positive regulation of protein kinase activity
GO:0045931	positive regulation of mitotic cell cycle