Mus musculus Gene: Pcna
Summary
InnateDB Gene IDBG-207308.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pcna
Gene Name proliferating cell nuclear antigen
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000027342
Encoded Proteins
proliferating cell nuclear antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:132249162-132253314
Strand Reverse strand
Band F2
Transcripts
ENSMUST00000028817 ENSMUSP00000028817
ENSMUST00000140338
ENSMUST00000136676
ENSMUST00000135181
ENSMUST00000149627
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated
Total 36 [view]
Protein-Protein 35 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030337 DNA polymerase processivity factor activity
Biological Process
GO:0000077 DNA damage checkpoint
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006272 leading strand elongation
GO:0006275 regulation of DNA replication
GO:0006287 base-excision repair, gap-filling
GO:0006298 mismatch repair
GO:0019985 translesion synthesis
GO:0032077 positive regulation of deoxyribonuclease activity
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005652 nuclear lamina
GO:0005657 replication fork
GO:0005813 centrosome
GO:0030896 checkpoint clamp complex
GO:0043626 PCNA complex
GO:0070557 PCNA-p21 complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Processive synthesis on the lagging strand pathway
Transcription-coupled NER (TC-NER) pathway
Removal of the Flap Intermediate pathway
Cell Cycle, Mitotic pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Chromosome Maintenance pathway
Synthesis of DNA pathway
DNA strand elongation pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
DNA Replication pathway
Base Excision Repair pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
G0 and Early G1 pathway
Global Genomic NER (GG-NER) pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Telomere Maintenance pathway
Cell Cycle pathway
Nucleotide Excision Repair pathway
Removal of the Flap Intermediate from the C-strand pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
DNA Repair pathway
Leading Strand Synthesis pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Removal of DNA patch containing abasic residue pathway
G1/S Transition pathway
Mitotic G1-G1/S phases pathway
Mismatch Repair pathway
Extension of Telomeres pathway
G1/S-Specific Transcription pathway
Polymerase switching pathway
Processive synthesis on the C-strand of the telomere pathway
E2F mediated regulation of DNA replication pathway
Lagging Strand Synthesis pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Resolution of Abasic Sites (AP sites) pathway
Polymerase switching on the C-strand of the telomere pathway
S Phase pathway
KEGG
DNA replication pathway
Base excision repair pathway
Nucleotide excision repair pathway
Mismatch repair pathway
Cell cycle pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P17918
TrEMBL Q542J9
UniProt Splice Variant
Entrez Gene 18538
UniGene Mm.396588 Mm.399522 Mm.428762 Mm.7141
RefSeq NM_011045
OMIM
CCDS CCDS16771
HPRD
IMGT
MGI ID MGI:97503
MGI Symbol Pcna
EMBL AK012932 AK088256 AK151238 AK151411 AK165217 AK168233 AK168596 BC005778 BC010343 CH466519 X53068 X57800
GenPept AAH05778 AAH10343 BAB28557 BAC40240 BAE30230 BAE30376 BAE38082 BAE40183 BAE40463 CAA37243 CAA40938 EDL28343
RNA Seq Atlas 18538