Version 5.4
Mus musculus Gene: Pcna
Summary
InnateDB Gene IDBG-207308.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pcna
Gene Name proliferating cell nuclear antigen
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000027342
Encoded Proteins
IDBP-207310
proliferating cell nuclear antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:132249162-132253314
Strand Reverse strand
Band F2
Transcripts
ENSMUST00000028817 ENSMUSP00000028817
ENSMUST00000140338
ENSMUST00000136676
ENSMUST00000135181
ENSMUST00000149627
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated
Total 36 [view]
Protein-Protein 35 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030337 DNA polymerase processivity factor activity
Biological Process
GO:0000077 DNA damage checkpoint
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006272 leading strand elongation
GO:0006275 regulation of DNA replication
GO:0006287 base-excision repair, gap-filling
GO:0006298 mismatch repair
GO:0019985 translesion synthesis
GO:0032077 positive regulation of deoxyribonuclease activity
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005652 nuclear lamina
GO:0005657 replication fork
GO:0005813 centrosome
GO:0030896 checkpoint clamp complex
GO:0043626 PCNA complex
GO:0070557 PCNA-p21 complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_262992
Processive synthesis on the lagging strand pathway
REACT_213655
Transcription-coupled NER (TC-NER) pathway
REACT_251075
Removal of the Flap Intermediate pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_202316
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_233453
Chromosome Maintenance pathway
REACT_258062
Synthesis of DNA pathway
REACT_241296
DNA strand elongation pathway
REACT_219381
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
REACT_232628
DNA Replication pathway
REACT_245705
Base Excision Repair pathway
REACT_227394
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_199110
G0 and Early G1 pathway
REACT_238177
Global Genomic NER (GG-NER) pathway
REACT_237585
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_252672
Telomere Maintenance pathway
REACT_188804
Cell Cycle pathway
REACT_235422
Nucleotide Excision Repair pathway
REACT_216529
Removal of the Flap Intermediate from the C-strand pathway
REACT_209299
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
REACT_233397
DNA Repair pathway
REACT_259967
Leading Strand Synthesis pathway
REACT_220175
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_246095
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
REACT_219337
Removal of DNA patch containing abasic residue pathway
REACT_253002
G1/S Transition pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_236124
Mismatch Repair pathway
REACT_252545
Extension of Telomeres pathway
REACT_198608
G1/S-Specific Transcription pathway
REACT_245471
Polymerase switching pathway
REACT_223154
Processive synthesis on the C-strand of the telomere pathway
REACT_206830
E2F mediated regulation of DNA replication pathway
REACT_245263
Lagging Strand Synthesis pathway
REACT_240368
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
REACT_250836
Resolution of Abasic Sites (AP sites) pathway
REACT_225604
Polymerase switching on the C-strand of the telomere pathway
REACT_253623
S Phase pathway
KEGG
mmu03030
DNA replication pathway
mmu04110
Cell cycle pathway
mmu03420
Nucleotide excision repair pathway
mmu03410
Base excision repair pathway
mmu03430
Mismatch repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.396588 Mm.399522 Mm.428762 Mm.7141
RefSeq NM_011045
OMIM
CCDS CCDS16771
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca