Version 5.4
Mus musculus Gene: Actb
Summary
InnateDB Gene IDBG-207470.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Actb
Gene Name actin, beta
Synonyms Actx; beta-actin; E430023M04Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000029580
Encoded Proteins
IDBP-207474
actin, beta
IDBP-269236
actin, beta
IDBP-621359
actin, beta
IDBP-621361
actin, beta
IDBP-621364
actin, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075624:
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:142903115-142906754
Strand Reverse strand
Band G2
Transcripts
ENSMUST00000100497 ENSMUSP00000098066
ENSMUST00000106216 ENSMUSP00000101823
ENSMUST00000167721 ENSMUSP00000127663
ENSMUST00000171419 ENSMUSP00000130611
ENSMUST00000167386
ENSMUST00000163829 ENSMUSP00000132135
ENSMUST00000165629
ENSMUST00000164765
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 185 interaction(s) predicted by orthology.
Experimentally validated
Total 70 [view]
Protein-Protein 67 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 185 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019894 kinesin binding
GO:0019901 protein kinase binding
GO:0030957 Tat protein binding
GO:0031492 nucleosomal DNA binding
GO:0050998 nitric-oxide synthase binding
Biological Process
GO:0001895 retina homeostasis
GO:0007409 axonogenesis
GO:0021762 substantia nigra development
GO:0043044 ATP-dependent chromatin remodeling
Cellular Component
GO:0000790 nuclear chromatin
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030424 axon
GO:0030529 ribonucleoprotein complex
GO:0030863 cortical cytoskeleton
GO:0035267 NuA4 histone acetyltransferase complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
GO:0070688 MLL5-L complex
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000075624
View Gene Order
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_224389
Gap junction trafficking and regulation pathway
REACT_218274
Chromatin organization pathway
REACT_224553
Hemostasis pathway
REACT_257923
Recycling pathway of L1 pathway
REACT_209837
Membrane Trafficking pathway
REACT_227951
Signaling by VEGF pathway
REACT_220352
Formation of annular gap junctions pathway
REACT_226917
HATs acetylate histones pathway
REACT_258900
Chaperonin-mediated protein folding pathway
REACT_248094
Cell-cell junction organization pathway
REACT_252491
Folding of actin by CCT/TriC pathway
REACT_230745
Immune System pathway
REACT_247926
Metabolism of proteins pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
REACT_260833
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_209040
Gap junction degradation pathway
REACT_244931
Interaction between L1 and Ankyrins pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_245534
Protein folding pathway
REACT_230395
Adherens junctions interactions pathway
REACT_257656
EPHB-mediated forward signaling pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_243772
Cell-extracellular matrix interactions pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_219680
L1CAM interactions pathway
REACT_188576
Developmental Biology pathway
REACT_217189
Gap junction trafficking pathway
REACT_188257
Signal Transduction pathway
REACT_241978
Cell junction organization pathway
REACT_223082
Cell-Cell communication pathway
REACT_199054
Translocation of GLUT4 to the plasma membrane pathway
REACT_245663
Prefoldin mediated transfer of substrate to CCT/TriC pathway
KEGG
mmu04530
Tight junction pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04520
Adherens junction pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04510
Focal adhesion pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
mmu05416
Viral myocarditis pathway
mmu04971
Gastric acid secretion pathway
mmu04145
Phagosome pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_17050
Folding of actin by CCT/TriC pathway
REACT_16936
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_11049
Formation of annular gap junctions pathway
REACT_11035
Gap junction degradation pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_20649
Cell-extracellular matrix interactions pathway
REACT_19195
Adherens junctions interactions pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22266
Interaction between L1 and Ankyrins pathway
REACT_22205
L1CAM interactions pathway
REACT_172610
HATs acetylate histones pathway
REACT_16952
Protein folding pathway
REACT_111045
Developmental Biology pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_9411
Gap junction trafficking pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_17015
Metabolism of proteins pathway
REACT_6900
Immune System pathway
REACT_17029
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_172623
Chromatin organization pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_19331
Cell-cell junction organization pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_604
Hemostasis pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05110
Vibrio cholerae infection pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04520
Adherens junction pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa04510
Focal adhesion pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05414
Dilated cardiomyopathy pathway
hsa05416
Viral myocarditis pathway
hsa04971
Gastric acid secretion pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
hsa04145
Phagosome pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL E9Q1F2 Q6IWE2 Q99NC5
UniProt Splice Variant
Entrez Gene 11461
UniGene Mm.391967 Mm.399519 Mm.468932 Mm.469717
RefSeq NM_007393
OMIM
CCDS CCDS19833
HPRD
IMGT
MGI ID MGI:87904
MGI Symbol Actb
EMBL AB028847 AC144818 AY618569
GenPept AAT40730 BAB40317
RNA Seq Atlas 11461

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca