Mus musculus Gene: Actb
Summary
InnateDB Gene IDBG-207470.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Actb
Gene Name actin, beta
Synonyms Actx; beta-actin; E430023M04Rik;
Species Mus musculus
Ensembl Gene ENSMUSG00000029580
Encoded Proteins
actin, beta
actin, beta
actin, beta
actin, beta
actin, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075624:
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:142903115-142906754
Strand Reverse strand
Band G2
Transcripts
ENSMUST00000100497 ENSMUSP00000098066
ENSMUST00000106216 ENSMUSP00000101823
ENSMUST00000167721 ENSMUSP00000127663
ENSMUST00000171419 ENSMUSP00000130611
ENSMUST00000167386
ENSMUST00000163829 ENSMUSP00000132135
ENSMUST00000165629
ENSMUST00000164765
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 185 interaction(s) predicted by orthology.
Experimentally validated
Total 70 [view]
Protein-Protein 67 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 185 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019894 kinesin binding
GO:0019901 protein kinase binding
GO:0030957 Tat protein binding
GO:0031492 nucleosomal DNA binding
GO:0050998 nitric-oxide synthase binding
Biological Process
GO:0001895 retina homeostasis
GO:0007409 axonogenesis
GO:0021762 substantia nigra development
GO:0043044 ATP-dependent chromatin remodeling
Cellular Component
GO:0000790 nuclear chromatin
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030424 axon
GO:0030529 ribonucleoprotein complex
GO:0030863 cortical cytoskeleton
GO:0035267 NuA4 histone acetyltransferase complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
GO:0070688 MLL5-L complex
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Regulation of actin dynamics for phagocytic cup formation pathway
Gap junction trafficking and regulation pathway
Chromatin organization pathway
Hemostasis pathway
Recycling pathway of L1 pathway
Membrane Trafficking pathway
Signaling by VEGF pathway
Formation of annular gap junctions pathway
HATs acetylate histones pathway
Chaperonin-mediated protein folding pathway
Cell-cell junction organization pathway
Folding of actin by CCT/TriC pathway
Immune System pathway
Metabolism of proteins pathway
Chromatin modifying enzymes pathway
Factors involved in megakaryocyte development and platelet production pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
Gap junction degradation pathway
Interaction between L1 and Ankyrins pathway
EPH-Ephrin signaling pathway
Protein folding pathway
Adherens junctions interactions pathway
EPHB-mediated forward signaling pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
Cell-extracellular matrix interactions pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
L1CAM interactions pathway
Developmental Biology pathway
Gap junction trafficking pathway
Signal Transduction pathway
Cell junction organization pathway
Cell-Cell communication pathway
Translocation of GLUT4 to the plasma membrane pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
KEGG
Phagosome pathway
Focal adhesion pathway
Adherens junction pathway
Tight junction pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
Gastric acid secretion pathway
Bacterial invasion of epithelial cells pathway
Hypertrophic cardiomyopathy (HCM) pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Dilated cardiomyopathy pathway
Viral myocarditis pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
REACTOME
HATs acetylate histones pathway
Protein folding pathway
Regulation of actin dynamics for phagocytic cup formation pathway
Developmental Biology pathway
Gap junction degradation pathway
Interaction between L1 and Ankyrins pathway
Cell-Cell communication pathway
Cell junction organization pathway
EPHB-mediated forward signaling pathway
Formation of annular gap junctions pathway
Signaling by VEGF pathway
Folding of actin by CCT/TriC pathway
Innate Immune System pathway
Axon guidance pathway
Signal Transduction pathway
Gap junction trafficking pathway
Chaperonin-mediated protein folding pathway
Recycling pathway of L1 pathway
Metabolism of proteins pathway
Immune System pathway
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
VEGFA-VEGFR2 Pathway pathway
Chromatin organization pathway
Translocation of GLUT4 to the plasma membrane pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
L1CAM interactions pathway
Factors involved in megakaryocyte development and platelet production pathway
Chromatin modifying enzymes pathway
EPH-ephrin mediated repulsion of cells pathway
Prefoldin mediated transfer of substrate to CCT/TriC pathway
EPH-Ephrin signaling pathway
Cell-cell junction organization pathway
Adherens junctions interactions pathway
Gap junction trafficking and regulation pathway
Cell-extracellular matrix interactions pathway
Hemostasis pathway
Membrane Trafficking pathway
KEGG
Phagosome pathway
Focal adhesion pathway
Adherens junction pathway
Tight junction pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
Gastric acid secretion pathway
Bacterial invasion of epithelial cells pathway
Vibrio cholerae infection pathway
Pathogenic Escherichia coli infection pathway
Shigellosis pathway
Hypertrophic cardiomyopathy (HCM) pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Dilated cardiomyopathy pathway
Viral myocarditis pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
The information processing pathway at the ifn beta enhancer [Biocarta view]
Chromatin remodeling by hswi/snf atp-dependent complexes [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.391967 Mm.399519 Mm.468932 Mm.469717
RefSeq NM_007393
OMIM
CCDS CCDS19833
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas