InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Actb

Summary

InnateDB Protein

IDBP-207474.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Actb

Protein Name

actin, beta

Synonyms

Actx; beta-actin; E430023M04Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098066

InnateDB Gene

IDBG-207470 (Actb)

Protein Structure

UniProt Annotation

Function

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Subcellular Localization

Cytoplasm, cytoskeleton. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 185 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	67 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	185 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019894	kinesin binding
GO:0019901	protein kinase binding
GO:0030957	Tat protein binding
GO:0031492	nucleosomal DNA binding
GO:0050998	nitric-oxide synthase binding

Biological Process

GO:0001895	retina homeostasis
GO:0007409	axonogenesis
GO:0021762	substantia nigra development
GO:0043044	ATP-dependent chromatin remodeling

Cellular Component

GO:0000790	nuclear chromatin
GO:0005615	extracellular space
GO:0005829	cytosol
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030424	axon
GO:0030529	ribonucleoprotein complex
GO:0030863	cortical cytoskeleton
GO:0035267	NuA4 histone acetyltransferase complex
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0070688	MLL5-L complex
GO:0072562	blood microparticle