Mus musculus Gene: Bmp2
Summary
InnateDB Gene IDBG-207600.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bmp2
Gene Name bone morphogenetic protein 2
Synonyms AI467020; Bmp2a;
Species Mus musculus
Ensembl Gene ENSMUSG00000027358
Encoded Proteins
bone morphogenetic protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of secreted factors that participate in developmental signal transduction to stimulate SMAD transcriptional activators. The encoded protein is able to induce cartilage and bone formation. The propeptide is further cleaved into an active chain. [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:133552159-133562885
Strand Forward strand
Band F2
Transcripts
ENSMUST00000028836 ENSMUSP00000028836
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004745 retinol dehydrogenase activity
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0019211 phosphatase activator activity
GO:0046332 SMAD binding
GO:0046982 protein heterodimerization activity
GO:0070700 BMP receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000187 activation of MAPK activity
GO:0001649 osteoblast differentiation
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001837 epithelial to mesenchymal transition
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002062 chondrocyte differentiation
GO:0003130 BMP signaling pathway involved in heart induction
GO:0003181 atrioventricular valve morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003308 negative regulation of Wnt receptor signaling pathway involved in heart development
GO:0006029 proteoglycan metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0007507 heart development
GO:0008285 negative regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010894 negative regulation of steroid biosynthetic process
GO:0010922 positive regulation of phosphatase activity
GO:0021537 telencephalon development
GO:0021978 telencephalon regionalization
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030282 bone mineralization
GO:0030335 positive regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0031648 protein destabilization
GO:0032348 negative regulation of aldosterone biosynthetic process
GO:0033690 positive regulation of osteoblast proliferation
GO:0035051 cardiac cell differentiation
GO:0035054 embryonic heart tube anterior/posterior pattern specification
GO:0035630 bone mineralization involved in bone maturation
GO:0040007 growth
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042482 positive regulation of odontogenesis
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0043065 positive regulation of apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
GO:0045165 cell fate commitment
GO:0045597 positive regulation of cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045786 negative regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048711 positive regulation of astrocyte differentiation
GO:0048762 mesenchymal cell differentiation
GO:0048839 inner ear development
GO:0050769 positive regulation of neurogenesis
GO:0051042 negative regulation of calcium-independent cell-cell adhesion
GO:0055007 cardiac muscle cell differentiation
GO:0055008 cardiac muscle tissue morphogenesis
GO:0055114 oxidation-reduction process
GO:0060039 pericardium development
GO:0060128 corticotropin hormone secreting cell differentiation
GO:0060129 thyroid-stimulating hormone-secreting cell differentiation
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060485 mesenchyme development
GO:0060804 positive regulation of Wnt receptor signaling pathway by BMP signaling pathway
GO:0061036 positive regulation of cartilage development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071363 cellular response to growth factor stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071773 cellular response to BMP stimulus
GO:0072138 mesenchymal cell proliferation involved in ureteric bud development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1900745 positive regulation of p38MAPK cascade
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:2000065 negative regulation of cortisol biosynthetic process
GO:2000726 negative regulation of cardiac muscle cell differentiation
Cellular Component
GO:0005615 extracellular space
GO:0009986 cell surface
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Elastic fibre formation pathway
Molecules associated with elastic fibres pathway
Signaling by BMP pathway
Extracellular matrix organization pathway
Signal Transduction pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Hedgehog signaling pathway pathway
TGF-beta signaling pathway pathway
Pathways in cancer pathway
Basal cell carcinoma pathway
INOH
GPCR signaling pathway
BMP2 signaling pathway
TGF-beta signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Elastic fibre formation pathway
Extracellular matrix organization pathway
Molecules associated with elastic fibres pathway
Signal Transduction pathway
Signaling by BMP pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Hedgehog signaling pathway pathway
TGF-beta signaling pathway pathway
Pathways in cancer pathway
Basal cell carcinoma pathway
INOH
GPCR signaling pathway
TGF-beta signaling pathway
BMP2 signaling pathway
PID BIOCARTA
Alk in cardiac myocytes [Biocarta view]
PID NCI
Cross-References
SwissProt P21274
TrEMBL
UniProt Splice Variant
Entrez Gene 12156
UniGene Mm.103205
RefSeq NM_007553
OMIM
CCDS CCDS16782
HPRD
IMGT
MGI ID MGI:88177
MGI Symbol Bmp2
EMBL AK133923 AK161862 AL831753 BC100344 CH466519 L25602
GenPept AAB05665 AAI00345 BAE21928 BAE36612 CAM22737 EDL28371
RNA Seq Atlas 12156