Homo sapiens Gene: GZMK
Summary
InnateDB Gene IDBG-20767.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GZMK
Gene Name granzyme K (granzyme 3; tryptase II)
Synonyms TRYP2;
Species Homo sapiens
Ensembl Gene ENSG00000113088
Encoded Proteins
granzyme K (granzyme 3; tryptase II)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008]
This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface \'nonself\' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:55024253-55034570
Strand Forward strand
Band q11.2
Transcripts
ENST00000231009 ENSP00000231009
ENST00000512089
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt P49863
TrEMBL
UniProt Splice Variant
Entrez Gene 3003
UniGene
RefSeq NM_002104
HUGO HGNC:4711
OMIM 600784
CCDS CCDS3964
HPRD 02872
IMGT
EMBL AK312074 BC035802 CH471123 U26174 U35237
GenPept AAA74578 AAA79063 AAH35802 BAG35010 EAW54899
RNA Seq Atlas 3003