Version 5.4
Mus musculus Gene: Plcb1
Summary
InnateDB Gene IDBG-207677.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plcb1
Gene Name phospholipase C, beta 1
Synonyms 3110043I21Rik; AI132408; mKIAA0581; Plcb;
Species Mus musculus
Ensembl Gene ENSMUSG00000051177
Encoded Proteins
IDBP-207681
phospholipase C, beta 1
IDBP-260960
phospholipase C, beta 1
IDBP-536455
phospholipase C, beta 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182621:
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:134786159-135475258
Strand Forward strand
Band F3
Transcripts
ENSMUST00000070724 ENSMUSP00000064844
ENSMUST00000110116 ENSMUSP00000105743
ENSMUST00000130524
ENSMUST00000129382
ENSMUST00000131552 ENSMUSP00000118756
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004871 signal transducer activity
GO:0005096 GTPase activator activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005521 lamin binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0008081 phosphoric diester hydrolase activity
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0001556 oocyte maturation
GO:0006397 mRNA processing
GO:0006629 lipid metabolic process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway
GO:0007215 glutamate receptor signaling pathway
GO:0007420 brain development
GO:0007613 memory
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0008286 insulin receptor signaling pathway
GO:0016042 lipid catabolic process
GO:0021987 cerebral cortex development
GO:0030218 erythrocyte differentiation
GO:0030225 macrophage differentiation
GO:0032417 positive regulation of sodium:proton antiporter activity
GO:0032735 positive regulation of interleukin-12 production
GO:0035556 intracellular signal transduction
GO:0035722 interleukin-12-mediated signaling pathway
GO:0035723 interleukin-15-mediated signaling pathway
GO:0040019 positive regulation of embryonic development
GO:0043547 positive regulation of GTPase activity
GO:0045444 fat cell differentiation
GO:0045663 positive regulation of myoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046330 positive regulation of JNK cascade
GO:0046488 phosphatidylinositol metabolic process
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048639 positive regulation of developmental growth
GO:0060466 activation of meiosis involved in egg activation
GO:0070498 interleukin-1-mediated signaling pathway
GO:0080154 regulation of fertilization
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2000344 positive regulation of acrosome reaction
GO:2000438 negative regulation of monocyte extravasation
GO:2000560 positive regulation of CD24 biosynthetic process
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016607 nuclear speck
GO:0031965 nuclear membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSG00000182621
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000008338
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_258788
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
REACT_223625
GPCR downstream signaling pathway
REACT_214014
Signaling by Wnt pathway
REACT_254215
Signaling by GPCR pathway
REACT_217323
Integration of energy metabolism pathway
REACT_262889
G beta:gamma signalling through PLC beta pathway
REACT_198685
Activation of Kainate Receptors upon glutamate binding pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_247495
Acetylcholine regulates insulin secretion pathway
REACT_226355
beta-catenin independent WNT signaling pathway
REACT_188937
Metabolism pathway
REACT_263148
Regulation of insulin secretion pathway
REACT_221970
Ca2+ pathway pathway
REACT_259290
Neuronal System pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_242845
Opioid Signalling pathway
REACT_198612
Presynaptic function of Kainate receptors pathway
REACT_207835
G-protein beta:gamma signalling pathway
REACT_188257
Signal Transduction pathway
REACT_196476
Inositol phosphate metabolism pathway
REACT_196473
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_251998
Free fatty acids regulate insulin secretion pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_253342
PLC beta mediated events pathway
REACT_248370
G-protein mediated events pathway
KEGG
mmu00562
Inositol phosphate metabolism pathway
mmu04020
Calcium signaling pathway pathway
mmu04062
Chemokine signaling pathway pathway
mmu04070
Phosphatidylinositol signaling system pathway
mmu04270
Vascular smooth muscle contraction pathway
mmu04310
Wnt signaling pathway pathway
mmu04540
Gap junction pathway
mmu04720
Long-term potentiation pathway
mmu04730
Long-term depression pathway
mmu04912
GnRH signaling pathway pathway
mmu04916
Melanogenesis pathway
mmu04970
Salivary secretion pathway
mmu04971
Gastric acid secretion pathway
mmu04972
Pancreatic secretion pathway
mmu05010
Alzheimer's disease pathway
mmu05016
Huntington's disease pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
mmu05143
African trypanosomiasis pathway
mmu05146
Amoebiasis pathway
INOH
INOH website
GPCR signaling pathway
INOH website
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_14
IL2 pathway
REACTOME
REACT_1505
Integration of energy metabolism pathway
REACT_21254
Presynaptic function of Kainate receptors pathway
REACT_172761
Ca2+ pathway pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_13685
Neuronal System pathway
REACT_14797
Signaling by GPCR pathway
REACT_15426
PLC beta mediated events pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_19193
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
REACT_15295
Opioid Signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_18405
Acetylcholine regulates insulin secretion pathway
REACT_15526
G-protein mediated events pathway
REACT_21312
Activation of Kainate Receptors upon glutamate binding pathway
REACT_19375
Free fatty acids regulate insulin secretion pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_19145
G beta:gamma signalling through PLC beta pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_111217
Metabolism pathway
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_216130
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
REACT_212636
Signaling by Wnt pathway
REACT_208875
Activation of Kainate Receptors upon glutamate binding pathway
REACT_205036
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_209110
Regulation of insulin secretion pathway
REACT_205369
Signaling by GPCR pathway
REACT_203404
Free fatty acids regulate insulin secretion pathway
REACT_217101
Integration of energy metabolism pathway
REACT_223058
Transmission across Chemical Synapses pathway
REACT_225102
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_209727
Ca2+ pathway pathway
REACT_214353
Signal Transduction pathway
REACT_211557
G-protein mediated events pathway
REACT_202705
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_206800
beta-catenin independent WNT signaling pathway
REACT_209521
G alpha (q) signalling events pathway
REACT_214436
GPCR downstream signaling pathway
REACT_213422
PLC beta mediated events pathway
REACT_225032
Neuronal System pathway
REACT_219139
Metabolism pathway
REACT_203136
G-protein beta:gamma signalling pathway
REACT_211106
Inositol phosphate metabolism pathway
REACT_224596
G beta:gamma signalling through PLC beta pathway
REACT_219672
Opioid Signalling pathway
REACT_217228
Presynaptic function of Kainate receptors pathway
REACT_202864
Acetylcholine regulates insulin secretion pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04020
Calcium signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04310
Wnt signaling pathway pathway
hsa04540
Gap junction pathway
hsa04720
Long-term potentiation pathway
hsa04730
Long-term depression pathway
hsa04912
GnRH signaling pathway pathway
hsa04916
Melanogenesis pathway
hsa04970
Salivary secretion pathway
hsa04971
Gastric acid secretion pathway
hsa04972
Pancreatic secretion pathway
hsa05010
Alzheimer's disease pathway
hsa05016
Huntington's disease pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa05143
African trypanosomiasis pathway
hsa05146
Amoebiasis pathway
INOH
INOH website
GPCR signaling pathway
INOH website
Inositol phosphate metabolism pathway
INOH website
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
PID BIOCARTA
100030
Aspirin blocks signaling pathway involved in platelet activation [Biocarta view]
100215
Ccr3 signaling in eosinophils [Biocarta view]
100180
Eicosanoid metabolism [Biocarta view]
100082
Thrombin signaling and protease-activated receptors [Biocarta view]
100069
Phospholipase c signaling pathway [Biocarta view]
100162
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
100201
Regulation of ck1/cdk5 by type 1 glutamate receptors [Biocarta view]
100100
Pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase [Biocarta view]
100073
Activation of pkc through g-protein coupled receptors [Biocarta view]
100209
Cadmium induces dna synthesis and proliferation in macrophages [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.405153
RefSeq NM_001145830 NM_019677 XM_006498930
OMIM
CCDS CCDS16787 CCDS50729
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca