Mus musculus Gene: Plcb1
Summary
InnateDB Gene IDBG-207677.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plcb1
Gene Name phospholipase C, beta 1
Synonyms 3110043I21Rik; AI132408; mKIAA0581; Plcb;
Species Mus musculus
Ensembl Gene ENSMUSG00000051177
Encoded Proteins
phospholipase C, beta 1
phospholipase C, beta 1
phospholipase C, beta 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182621:
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:134786159-135475258
Strand Forward strand
Band F3
Transcripts
ENSMUST00000070724 ENSMUSP00000064844
ENSMUST00000110116 ENSMUSP00000105743
ENSMUST00000130524
ENSMUST00000129382
ENSMUST00000131552 ENSMUSP00000118756
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004871 signal transducer activity
GO:0005096 GTPase activator activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005521 lamin binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0008081 phosphoric diester hydrolase activity
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0001556 oocyte maturation
GO:0006397 mRNA processing
GO:0006629 lipid metabolic process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway
GO:0007215 glutamate receptor signaling pathway
GO:0007420 brain development
GO:0007613 memory
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0008286 insulin receptor signaling pathway
GO:0016042 lipid catabolic process
GO:0021987 cerebral cortex development
GO:0030218 erythrocyte differentiation
GO:0030225 macrophage differentiation
GO:0032417 positive regulation of sodium:proton antiporter activity
GO:0032735 positive regulation of interleukin-12 production
GO:0035556 intracellular signal transduction
GO:0035722 interleukin-12-mediated signaling pathway
GO:0035723 interleukin-15-mediated signaling pathway
GO:0040019 positive regulation of embryonic development
GO:0043547 positive regulation of GTPase activity
GO:0045444 fat cell differentiation
GO:0045663 positive regulation of myoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046330 positive regulation of JNK cascade
GO:0046488 phosphatidylinositol metabolic process
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048639 positive regulation of developmental growth
GO:0060466 activation of meiosis involved in egg activation
GO:0070498 interleukin-1-mediated signaling pathway
GO:0080154 regulation of fertilization
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2000344 positive regulation of acrosome reaction
GO:2000438 negative regulation of monocyte extravasation
GO:2000560 positive regulation of CD24 biosynthetic process
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016607 nuclear speck
GO:0031965 nuclear membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
GPCR downstream signaling pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
Integration of energy metabolism pathway
G beta:gamma signalling through PLC beta pathway
Activation of Kainate Receptors upon glutamate binding pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Acetylcholine regulates insulin secretion pathway
beta-catenin independent WNT signaling pathway
Metabolism pathway
Regulation of insulin secretion pathway
Ca2+ pathway pathway
Neuronal System pathway
G alpha (q) signalling events pathway
Opioid Signalling pathway
Presynaptic function of Kainate receptors pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
Inositol phosphate metabolism pathway
Synthesis of IP3 and IP4 in the cytosol pathway
Free fatty acids regulate insulin secretion pathway
Transmission across Chemical Synapses pathway
PLC beta mediated events pathway
G-protein mediated events pathway
KEGG
Inositol phosphate metabolism pathway
Calcium signaling pathway pathway
Chemokine signaling pathway pathway
Phosphatidylinositol signaling system pathway
Vascular smooth muscle contraction pathway
Wnt signaling pathway pathway
Gap junction pathway
Long-term potentiation pathway
Long-term depression pathway
GnRH signaling pathway pathway
Melanogenesis pathway
Salivary secretion pathway
Gastric acid secretion pathway
Pancreatic secretion pathway
Alzheimer's disease pathway
Huntington's disease pathway
Chagas disease (American trypanosomiasis) pathway
African trypanosomiasis pathway
Amoebiasis pathway
INOH
GPCR signaling pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
IL2 pathway
REACTOME
Integration of energy metabolism pathway
Presynaptic function of Kainate receptors pathway
Ca2+ pathway pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by GPCR pathway
PLC beta mediated events pathway
G-protein beta:gamma signalling pathway
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
Opioid Signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Acetylcholine regulates insulin secretion pathway
G-protein mediated events pathway
Activation of Kainate Receptors upon glutamate binding pathway
Free fatty acids regulate insulin secretion pathway
Transmission across Chemical Synapses pathway
G beta:gamma signalling through PLC beta pathway
Inositol phosphate metabolism pathway
Regulation of insulin secretion pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Synthesis of IP3 and IP4 in the cytosol pathway
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
Signaling by Wnt pathway
Activation of Kainate Receptors upon glutamate binding pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Regulation of insulin secretion pathway
Signaling by GPCR pathway
Free fatty acids regulate insulin secretion pathway
Integration of energy metabolism pathway
Transmission across Chemical Synapses pathway
Synthesis of IP3 and IP4 in the cytosol pathway
Ca2+ pathway pathway
Signal Transduction pathway
G-protein mediated events pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
beta-catenin independent WNT signaling pathway
G alpha (q) signalling events pathway
GPCR downstream signaling pathway
PLC beta mediated events pathway
Neuronal System pathway
Metabolism pathway
G-protein beta:gamma signalling pathway
Inositol phosphate metabolism pathway
G beta:gamma signalling through PLC beta pathway
Opioid Signalling pathway
Presynaptic function of Kainate receptors pathway
Acetylcholine regulates insulin secretion pathway
KEGG
Inositol phosphate metabolism pathway
Calcium signaling pathway pathway
Chemokine signaling pathway pathway
Phosphatidylinositol signaling system pathway
Vascular smooth muscle contraction pathway
Wnt signaling pathway pathway
Gap junction pathway
Long-term potentiation pathway
Long-term depression pathway
GnRH signaling pathway pathway
Melanogenesis pathway
Salivary secretion pathway
Gastric acid secretion pathway
Pancreatic secretion pathway
Alzheimer's disease pathway
Huntington's disease pathway
Chagas disease (American trypanosomiasis) pathway
African trypanosomiasis pathway
Amoebiasis pathway
INOH
GPCR signaling pathway
Inositol phosphate metabolism pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
PID BIOCARTA
Aspirin blocks signaling pathway involved in platelet activation [Biocarta view]
Ccr3 signaling in eosinophils [Biocarta view]
Eicosanoid metabolism [Biocarta view]
Thrombin signaling and protease-activated receptors [Biocarta view]
Phospholipase c signaling pathway [Biocarta view]
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
Regulation of ck1/cdk5 by type 1 glutamate receptors [Biocarta view]
Pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase [Biocarta view]
Activation of pkc through g-protein coupled receptors [Biocarta view]
Cadmium induces dna synthesis and proliferation in macrophages [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.405153
RefSeq NM_001145830 NM_019677 XM_006498930
OMIM
CCDS CCDS16787 CCDS50729
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas