InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PLCB1

Summary

InnateDB Gene

IDBG-52543.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLCB1

Gene Name

phospholipase C, beta 1 (phosphoinositide-specific)

Synonyms

EIEE12; PI-PLC; PLC-154; PLC-I; PLC154; PLCB1A; PLCB1B

Species

Homo sapiens

Ensembl Gene

ENSG00000182621

Encoded Proteins

IDBP-52545

phospholipase C, beta 1 (phosphoinositide-specific)

IDBP-52547

phospholipase C, beta 1 (phosphoinositide-specific)

IDBP-52549

phospholipase C, beta 1 (phosphoinositide-specific)

IDBP-295021

phospholipase C, beta 1 (phosphoinositide-specific)

IDBP-365876

phospholipase C, beta 1 (phosphoinositide-specific)

IDBP-365878

phospholipase C, beta 1 (phosphoinositide-specific)

IDBP-594744

phospholipase C, beta 1 (phosphoinositide-specific)

IDBP-813505

phospholipase C, beta 1 (phosphoinositide-specific)

IDBP-813506

phospholipase C, beta 1 (phosphoinositide-specific)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:8132177-8968356

Strand

Forward strand

Band

p12.3

Transcripts

ENST00000378641	ENSP00000367908
ENST00000338037	ENSP00000338185
ENST00000378637	ENSP00000367904
ENST00000404098	ENSP00000384001
ENST00000439627	ENSP00000391162
ENST00000437439	ENSP00000389911
ENST00000475958
ENST00000487210	ENSP00000431704
ENST00000494924
ENST00000617005	ENSP00000477664
ENST00000612075	ENSP00000479997

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	11 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004871	signal transducer activity
GO:0005096	GTPase activator activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005521	lamin binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0008081	phosphoric diester hydrolase activity
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
GO:0007215	glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007420	brain development
GO:0007613	memory
GO:0008152	metabolic process
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0016042	lipid catabolic process
GO:0021987	cerebral cortex development
GO:0032735	positive regulation of interleukin-12 production
GO:0035556	intracellular signal transduction
GO:0035722	interleukin-12-mediated signaling pathway
GO:0035723	interleukin-15-mediated signaling pathway
GO:0040019	positive regulation of embryonic development
GO:0043547	positive regulation of GTPase activity
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0045444	fat cell differentiation
GO:0045663	positive regulation of myoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046330	positive regulation of JNK cascade
GO:0046488	phosphatidylinositol metabolic process
GO:0048009	insulin-like growth factor receptor signaling pathway
GO:0048639	positive regulation of developmental growth
GO:0051726	regulation of cell cycle
GO:0060466	activation of meiosis involved in egg activation
GO:0070498	interleukin-1-mediated signaling pathway
GO:0080154	regulation of fertilization
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
GO:2000344	positive regulation of acrosome reaction
GO:2000438	negative regulation of monocyte extravasation
GO:2000560	positive regulation of CD24 biosynthetic process

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016607	nuclear speck
GO:0031965	nuclear membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000051177

View Gene Order

ENSBTAG00000008338

Not yet available

Pathways

NETPATH

NetPath_14

IL2 pathway

REACTOME

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_19145

G beta:gamma signalling through PLC beta pathway

REACT_15426

PLC beta mediated events pathway

REACT_15295

Opioid Signalling pathway

REACT_21254

Presynaptic function of Kainate receptors pathway

REACT_150312

Synthesis of IP3 and IP4 in the cytosol pathway

REACT_18405

Acetylcholine regulates insulin secretion pathway

REACT_19193

Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway

REACT_18325

Regulation of insulin secretion pathway

REACT_1505

Integration of energy metabolism pathway

REACT_172761

Ca2+ pathway pathway

REACT_172694

beta-catenin independent WNT signaling pathway

REACT_11045

Signaling by Wnt pathway

REACT_13685

Neuronal System pathway

REACT_14797

Signaling by GPCR pathway

REACT_19388

G-protein beta:gamma signalling pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_15526

G-protein mediated events pathway

REACT_21312

Activation of Kainate Receptors upon glutamate binding pathway

REACT_19375

Free fatty acids regulate insulin secretion pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_150154

Inositol phosphate metabolism pathway

REACT_15370

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

REACT_111217

Metabolism pathway

KEGG

hsa04912

GnRH signaling pathway pathway

hsa04540

Gap junction pathway

hsa04310

Wnt signaling pathway pathway

hsa00562

Inositol phosphate metabolism pathway

hsa04720

Long-term potentiation pathway

hsa05010

Alzheimer's disease pathway

hsa04070

Phosphatidylinositol signaling system pathway

hsa04730

Long-term depression pathway

hsa04020

Calcium signaling pathway pathway

hsa04916

Melanogenesis pathway

hsa04270

Vascular smooth muscle contraction pathway

hsa04062

Chemokine signaling pathway pathway

hsa05016

Huntington's disease pathway

hsa04971

Gastric acid secretion pathway

hsa05146

Amoebiasis pathway

hsa05142

Chagas disease (American trypanosomiasis) pathway

hsa04972

Pancreatic secretion pathway

hsa04970

Salivary secretion pathway

hsa05143

African trypanosomiasis pathway

INOH

INOH website

GPCR GroupI metabotropic glutamate receptor signaling pathway pathway

INOH website

GPCR signaling pathway

INOH website

Inositol phosphate metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.431173 Hs.608399 Hs.628998 Hs.662314

RefSeq

NM_015192 NM_182734 XM_005260681 XM_006723555

HUGO

OMIM

CCDS

CCDS13102 CCDS13103

HPRD

06177

IMGT

EMBL

GenPept

RNA Seq Atlas