InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mpo

Summary

InnateDB Gene

IDBG-207719.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mpo

Gene Name

myeloperoxidase

Synonyms

mKIAA4033

Species

Mus musculus

Ensembl Gene

ENSMUSG00000009350

Encoded Proteins

IDBP-207721

myeloperoxidase

IDBP-265626

myeloperoxidase

IDBP-400093

myeloperoxidase

IDBP-534891

myeloperoxidase

IDBP-620745

myeloperoxidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005381:
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008]
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:87793581-87804413

Strand

Forward strand

Band

Transcripts

ENSMUST00000020779	ENSMUSP00000020779
ENSMUST00000107930	ENSMUSP00000103563
ENSMUST00000121303	ENSMUSP00000112837
ENSMUST00000143021	ENSMUSP00000123371
ENSMUST00000146650	ENSMUSP00000128484
ENSMUST00000167903

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0008201	heparin binding
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0001878	response to yeast
GO:0002149	hypochlorous acid biosynthetic process
GO:0002679	respiratory burst involved in defense response
GO:0006979	response to oxidative stress
GO:0007568	aging
GO:0009612	response to mechanical stimulus
GO:0019430	removal of superoxide radicals
GO:0032094	response to food
GO:0032496	response to lipopolysaccharide
GO:0034374	low-density lipoprotein particle remodeling
GO:0042744	hydrogen peroxide catabolic process
GO:0044130	negative regulation of growth of symbiont in host
GO:0050832	defense response to fungus
GO:0055114	oxidation-reduction process
GO:1990268	response to gold nanoparticle

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0030141	secretory granule
GO:0042582	azurophil granule
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000005381

View Gene Order

ENSBTAG00000011616

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04145

Phagosome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04145

Phagosome pathway

INOH

PID NCI

cmyb_pathway

C-MYB transcription factor network

il23pathway

IL23-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.4668

RefSeq

NM_010824 XM_006532404 XM_006532405 XM_006536437 XM_006536438 XM_006536439

OMIM

CCDS

CCDS25217

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas