InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MPO

Summary

InnateDB Gene

IDBG-60932.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MPO

Gene Name

myeloperoxidase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000005381

Encoded Proteins

IDBP-60936

myeloperoxidase

IDBP-761535

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008]
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:58269856-58280935

Strand

Reverse strand

Band

q22

Transcripts

ENST00000225275	ENSP00000225275
ENST00000577220	ENSP00000464668
ENST00000581022
ENST00000580005
ENST00000578493

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	9 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004601	peroxidase activity
GO:0008201	heparin binding
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0001878	response to yeast
GO:0002149	hypochlorous acid biosynthetic process
GO:0002679	respiratory burst involved in defense response
GO:0006952	defense response
GO:0006979	response to oxidative stress
GO:0007568	aging
GO:0009612	response to mechanical stimulus
GO:0019430	removal of superoxide radicals
GO:0032094	response to food
GO:0032496	response to lipopolysaccharide
GO:0034374	low-density lipoprotein particle remodeling
GO:0042744	hydrogen peroxide catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0044130	negative regulation of growth of symbiont in host
GO:0050832	defense response to fungus
GO:0055114	oxidation-reduction process
GO:1990268	response to gold nanoparticle

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005764	lysosome
GO:0030141	secretory granule
GO:0042582	azurophil granule
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000009350

View Gene Order

ENSBTAG00000011616

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04145

Phagosome pathway

INOH

PID NCI

cmyb_pathway

C-MYB transcription factor network

il23pathway

IL23-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.458272 Hs.593778

RefSeq

NM_000250

HUGO

OMIM

CCDS

CCDS11604

HPRD

06102

IMGT

EMBL

GenPept

RNA Seq Atlas