Version 5.4
Mus musculus Gene: Dstn
Summary
InnateDB Gene IDBG-208372.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dstn
Gene Name destrin
Synonyms 2610043P17Rik; ADF; AU042046; corn1; Dsn; sid23p
Species Mus musculus
Ensembl Gene ENSMUSG00000015932
Encoded Proteins
IDBP-208374
destrin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125868:
The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:143915320-143943324
Strand Forward strand
Band G1
Transcripts
ENSMUST00000103172 ENSMUSP00000099461
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 62 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0006928 cellular component movement
GO:0030042 actin filament depolymerization
GO:0030836 positive regulation of actin filament depolymerization
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0030864 cortical actin cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000125868
View Gene Order
ENSBTAG00000015434
Not yet available
Cross-References
SwissProt Q9R0P5
TrEMBL Q4FK36
UniProt Splice Variant
Entrez Gene 56431
UniGene Mm.28919
RefSeq NM_019771
OMIM
CCDS CCDS16812
HPRD
IMGT
MGI ID MGI:1929270
MGI Symbol Dstn
EMBL AB025406 AK078898 BC131926 CH466519 CT010216
GenPept AAI31927 BAA84691 BAC37447 CAJ18424 EDL28434
RNA Seq Atlas 56431

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca