Homo sapiens Gene: GZMA
Summary
InnateDB Gene IDBG-20850.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GZMA
Gene Name granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
Synonyms CTLA3; HFSP;
Species Homo sapiens
Ensembl Gene ENSG00000145649
Encoded Proteins
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface \'nonself\' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:55102648-55110252
Strand Forward strand
Band q11.2
Transcripts
ENST00000274306 ENSP00000274306
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 33 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0019835 cytolysis
GO:0032078 negative regulation of endodeoxyribonuclease activity
GO:0043065 positive regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0051354 negative regulation of oxidoreductase activity
GO:0051603 proteolysis involved in cellular protein catabolic process
Cellular Component
GO:0001772 immunological synapse
GO:0005576 extracellular region
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
Tsp-1 induced apoptosis in microvascular endothelial cell [Biocarta view]
Granzyme a mediated apoptosis pathway [Biocarta view]
PID NCI
IL12-mediated signaling events
Cross-References
SwissProt P12544
TrEMBL
UniProt Splice Variant
Entrez Gene 3001
UniGene
RefSeq NM_006144
HUGO HGNC:4708
OMIM 140050
CCDS CCDS3965
HPRD
IMGT
EMBL AB284134 AC091977 BC015739 CR456968 M18737 U40006
GenPept AAA52647 AAD00009 AAH15739 BAF56159 CAG33249
RNA Seq Atlas 3001