InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GZMA

Summary

InnateDB Gene

IDBG-20850.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GZMA

Gene Name

granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)

Synonyms

CTLA3; HFSP

Species

Homo sapiens

Ensembl Gene

ENSG00000145649

Encoded Proteins

IDBP-20852

granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface \'nonself\' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:55102648-55110252

Strand

Forward strand

Band

q11.2

Transcripts

ENST00000274306

ENSP00000274306

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	33 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0006955	immune response
GO:0019835	cytolysis
GO:0032078	negative regulation of endodeoxyribonuclease activity
GO:0043065	positive regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0051354	negative regulation of oxidoreductase activity
GO:0051603	proteolysis involved in cellular protein catabolic process

Cellular Component

GO:0001772	immunological synapse
GO:0005576	extracellular region
GO:0005634	nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000023132

View Gene Order

ENSBTAG00000021958

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

il12_2pathway

IL12-mediated signaling events

Cross-References

SwissProt

P12544

TrEMBL

UniProt Splice Variant

Entrez Gene

3001

UniGene

RefSeq

NM_006144

HUGO

HGNC:4708

OMIM

140050

CCDS

CCDS3965

HPRD

IMGT

EMBL

AB284134 AC091977 BC015739 CR456968 M18737 U40006

GenPept

AAA52647 AAD00009 AAH15739 BAF56159 CAG33249

RNA Seq Atlas

3001