InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.58970

Summary

InnateDB Gene

IDBG-629315.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.58970

Gene Name

granzyme A precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021958

Encoded Proteins

IDBP-680737

granzyme A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145649:
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface \'nonself\' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:24033747-24042721

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000029273

ENSBTAP00000029273

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006508	proteolysis
GO:0032078	negative regulation of endodeoxyribonuclease activity
GO:0043065	positive regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0051354	negative regulation of oxidoreductase activity
GO:0051603	proteolysis involved in cellular protein catabolic process

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000145649

View Gene Order

ENSMUSG00000023132

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

mmu04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

il12_2pathway

IL12-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.58970

RefSeq

NM_001099095

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas