Mus musculus Gene: Pdx1
Summary
InnateDB Gene IDBG-209001.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pdx1
Gene Name pancreatic and duodenal homeobox 1
Synonyms IDX-1; IPF-1; Ipf1; Mody4; pdx-1; STF-1;
Species Mus musculus
Ensembl Gene ENSMUSG00000029644
Encoded Proteins
pancreatic and duodenal homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139515:
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:147269959-147278008
Strand Forward strand
Band G3
Transcripts
ENSMUST00000085591 ENSMUSP00000082729
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0032403 protein complex binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001889 liver development
GO:0003309 type B pancreatic cell differentiation
GO:0006006 glucose metabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007224 smoothened signaling pathway
GO:0007263 nitric oxide mediated signal transduction
GO:0007417 central nervous system development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009611 response to wounding
GO:0009749 response to glucose
GO:0010040 response to iron(II) ion
GO:0010157 response to chlorate
GO:0010260 organ senescence
GO:0010942 positive regulation of cell death
GO:0014070 response to organic cyclic compound
GO:0016331 morphogenesis of embryonic epithelium
GO:0030073 insulin secretion
GO:0030154 cell differentiation
GO:0031016 pancreas development
GO:0031017 exocrine pancreas development
GO:0031018 endocrine pancreas development
GO:0031100 organ regeneration
GO:0031667 response to nutrient levels
GO:0032024 positive regulation of insulin secretion
GO:0033273 response to vitamin
GO:0033993 response to lipid
GO:0034097 response to cytokine
GO:0035094 response to nicotine
GO:0042127 regulation of cell proliferation
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0043201 response to leucine
GO:0043279 response to alkaloid
GO:0043388 positive regulation of DNA binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048565 digestive tract development
GO:0048863 stem cell differentiation
GO:0051384 response to glucocorticoid
GO:0051594 detection of glucose
GO:0060290 transdifferentiation
GO:0070542 response to fatty acid
GO:1902236 negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:2000675 negative regulation of type B pancreatic cell apoptotic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Regulation of gene expression in early pancreatic precursor cells pathway
Regulation of gene expression in beta cells pathway
Developmental Biology pathway
Regulation of beta-cell development pathway
KEGG
Type II diabetes mellitus pathway
Maturity onset diabetes of the young pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
Regulation of beta-cell development pathway
Regulation of gene expression in early pancreatic precursor cells pathway
Regulation of gene expression in beta cells pathway
KEGG
Type II diabetes mellitus pathway
Maturity onset diabetes of the young pathway
INOH
PID BIOCARTA
PID NCI
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.357883 Mm.389714 Mm.487322
RefSeq NM_008814
OMIM
CCDS CCDS39398
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas