InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pdx1

Summary

InnateDB Protein

IDBP-209003.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdx1

Protein Name

pancreatic and duodenal homeobox 1

Synonyms

IDX-1; IPF-1; Ipf1; Mody4; pdx-1; STF-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000082729

InnateDB Gene

IDBG-209001 (Pdx1)

Protein Structure

UniProt Annotation

Function

Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'. {ECO:0000269PubMed:11279116, ECO:0000269PubMed:9710595}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:17052199}. Cytoplasm, cytosol {ECO:0000269PubMed:17052199}.

Disease Associations

Tissue Specificity

Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001046	core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0032403	protein complex binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001889	liver development
GO:0003309	type B pancreatic cell differentiation
GO:0006006	glucose metabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007224	smoothened signaling pathway
GO:0007263	nitric oxide mediated signal transduction
GO:0007417	central nervous system development
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009611	response to wounding
GO:0009749	response to glucose
GO:0010040	response to iron(II) ion
GO:0010157	response to chlorate
GO:0010260	organ senescence
GO:0010942	positive regulation of cell death
GO:0014070	response to organic cyclic compound
GO:0016331	morphogenesis of embryonic epithelium
GO:0030073	insulin secretion
GO:0030154	cell differentiation
GO:0031016	pancreas development
GO:0031017	exocrine pancreas development
GO:0031018	endocrine pancreas development
GO:0031100	organ regeneration
GO:0031667	response to nutrient levels
GO:0032024	positive regulation of insulin secretion
GO:0033273	response to vitamin
GO:0033993	response to lipid
GO:0034097	response to cytokine
GO:0035094	response to nicotine
GO:0042127	regulation of cell proliferation
GO:0042493	response to drug
GO:0042593	glucose homeostasis
GO:0043201	response to leucine
GO:0043279	response to alkaloid
GO:0043388	positive regulation of DNA binding
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048565	digestive tract development
GO:0048863	stem cell differentiation
GO:0051384	response to glucocorticoid
GO:0051594	detection of glucose
GO:0060290	transdifferentiation
GO:0070542	response to fatty acid
GO:1902236	negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:2000675	negative regulation of type B pancreatic cell apoptotic process