InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Plxna2

Summary

InnateDB Gene

IDBG-209284.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plxna2

Gene Name

plexin A2

Synonyms

2810428A13Rik; AA589422; AW457381; mKIAA0463; OCT; PlexA2; Plxn2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026640

Encoded Proteins

IDBP-209286

plexin A2

IDBP-533186

plexin A2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076356:
This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:194619829-194816869

Strand

Forward strand

Band

Transcripts

ENSMUST00000027952	ENSMUSP00000027952
ENSMUST00000125381
ENSMUST00000135664	ENSMUSP00000118087
ENSMUST00000124785

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0017154	semaphorin receptor activity

Biological Process

GO:0001756	somitogenesis
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0021915	neural tube development
GO:0021935	cerebellar granule cell precursor tangential migration
GO:0030334	regulation of cell migration
GO:0051642	centrosome localization
GO:0060037	pharyngeal system development
GO:0060174	limb bud formation
GO:0071526	semaphorin-plexin signaling pathway