Mus musculus Gene: Plxna2
Summary
InnateDB Gene IDBG-209284.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plxna2
Gene Name plexin A2
Synonyms 2810428A13Rik; AA589422; AW457381; mKIAA0463; OCT; PlexA2; Plxn2;
Species Mus musculus
Ensembl Gene ENSMUSG00000026640
Encoded Proteins
plexin A2
plexin A2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076356:
This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:194619829-194816869
Strand Forward strand
Band H6
Transcripts
ENSMUST00000027952 ENSMUSP00000027952
ENSMUST00000125381
ENSMUST00000135664 ENSMUSP00000118087
ENSMUST00000124785
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0017154 semaphorin receptor activity
Biological Process
GO:0001756 somitogenesis
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007275 multicellular organismal development
GO:0021915 neural tube development
GO:0021935 cerebellar granule cell precursor tangential migration
GO:0030334 regulation of cell migration
GO:0051642 centrosome localization
GO:0060037 pharyngeal system development
GO:0060174 limb bud formation
GO:0071526 semaphorin-plexin signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
Sema3A PAK dependent Axon repulsion pathway
Axon guidance pathway
Developmental Biology pathway
Semaphorin interactions pathway
CRMPs in Sema3A signaling pathway
Other semaphorin interactions pathway
KEGG
Axon guidance pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
Semaphorin interactions pathway
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
Other semaphorin interactions pathway
Axon guidance pathway
CRMPs in Sema3A signaling pathway
Sema3A PAK dependent Axon repulsion pathway
KEGG
Axon guidance pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 18845
UniGene Mm.2251 Mm.401004 Mm.432322
RefSeq NM_008882 XM_006497240
OMIM
CCDS CCDS35827
HPRD
IMGT
MGI ID MGI:107684
MGI Symbol Plxna2
EMBL
GenPept
RNA Seq Atlas 18845