Mus musculus Gene: Cr2
Summary
InnateDB Gene IDBG-209389.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cr2
Gene Name complement receptor 2
Synonyms C3DR; CD21; CD35; Cr-1; Cr-2; Cr1;
Species Mus musculus
Ensembl Gene ENSMUSG00000026616
Encoded Proteins
complement receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] CR2 (CD21) is a cell membrane receptor, with 15 or 16 extracellular short consensus repeats (SCRs), that promotes B lymphocyte responses and bridges innate and acquired immunity.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117322:
This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:195136811-195176715
Strand Reverse strand
Band H6
Transcripts
ENSMUST00000082321 ENSMUSP00000080938
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 1 [view]
Protein-DNA 11 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001848 complement binding
GO:0003677 DNA binding
GO:0004872 receptor activity
GO:0004875 complement receptor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0002430 complement receptor mediated signaling pathway
GO:0030183 B cell differentiation
GO:0042100 B cell proliferation
GO:0042113 B cell activation
Cellular Component
GO:0009897 external side of plasma membrane
GO:0043235 receptor complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
Complement and coagulation cascades pathway
Hematopoietic cell lineage pathway
B cell receptor signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
BCR pathway
REACTOME
KEGG
Complement and coagulation cascades pathway
Hematopoietic cell lineage pathway
B cell receptor signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL Q9CVM1 Q9DC83
UniProt Splice Variant
Entrez Gene 12902
UniGene Mm.235387 Mm.401997
RefSeq NM_007758 XM_006497221 XM_006497223 XM_006497224 XM_006497225
OMIM
CCDS CCDS15642
HPRD
IMGT
MGI ID MGI:88489
MGI Symbol Cr2
EMBL AC139206 AK003072 AK007487 BC109344
GenPept AAI09345 BAB22548 BAB25063
RNA Seq Atlas 12902