InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cr2

Summary

InnateDB Gene

IDBG-209389.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cr2

Gene Name

complement receptor 2

Synonyms

C3DR; CD21; CD35; Cr-1; Cr-2; Cr1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026616

Encoded Proteins

IDBP-209391

complement receptor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20558730

[Homo sapiens] CR2 (CD21) is a cell membrane receptor, with 15 or 16 extracellular short consensus repeats (SCRs), that promotes B lymphocyte responses and bridges innate and acquired immunity.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117322:
This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:195136811-195176715

Strand

Reverse strand

Band

Transcripts

ENSMUST00000082321

ENSMUSP00000080938

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	1 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001848	complement binding
GO:0003677	DNA binding
GO:0004872	receptor activity
GO:0004875	complement receptor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0002430	complement receptor mediated signaling pathway
GO:0030183	B cell differentiation
GO:0042100	B cell proliferation
GO:0042113	B cell activation

Cellular Component

GO:0009897	external side of plasma membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000117322

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

mmu04640

Hematopoietic cell lineage pathway

mmu04610

Complement and coagulation cascades pathway

mmu04662

B cell receptor signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_12

BCR pathway

REACTOME

KEGG

hsa04640

Hematopoietic cell lineage pathway

hsa04610

Complement and coagulation cascades pathway

hsa04662

B cell receptor signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

Q9CVM1 Q9DC83

UniProt Splice Variant

Entrez Gene

12902

UniGene

Mm.235387 Mm.401997

RefSeq

NM_007758 XM_006497221 XM_006497223 XM_006497224 XM_006497225

OMIM

CCDS

CCDS15642

HPRD

IMGT

MGI ID

MGI:88489

MGI Symbol

Cr2

EMBL

AC139206 AK003072 AK007487 BC109344

GenPept

AAI09345 BAB22548 BAB25063

RNA Seq Atlas

12902