InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LIMK1

Summary

InnateDB Gene

IDBG-20945.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIMK1

Gene Name

LIM domain kinase 1

Synonyms

LIMK; LIMK-1

Species

Homo sapiens

Ensembl Gene

ENSG00000106683

Encoded Proteins

IDBP-20947

LIM domain kinase 1

IDBP-378634

LIM domain kinase 1

IDBP-378640

LIM domain kinase 1

IDBP-586814

LIM domain kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:74082933-74122525

Strand

Forward strand

Band

q11.23

Transcripts

ENST00000336180	ENSP00000336740
ENST00000418310	ENSP00000409717
ENST00000435201	ENSP00000414606
ENST00000486361
ENST00000491052
ENST00000483414
ENST00000476792
ENST00000538333	ENSP00000444452

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	52 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0031072	heat shock protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007266	Rho protein signal transduction
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0009103	lipopolysaccharide biosynthetic process
GO:0030036	actin cytoskeleton organization
GO:0032233	positive regulation of actin filament bundle assembly
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response
GO:0045773	positive regulation of axon extension
GO:0051444	negative regulation of ubiquitin-protein transferase activity
GO:0051496	positive regulation of stress fiber assembly