Mus musculus Gene: Csnk2a1
Summary
InnateDB Gene IDBG-209641.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Csnk2a1
Gene Name casein kinase 2, alpha 1 polypeptide
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000074698
Encoded Proteins
casein kinase 2, alpha 1 polypeptide
casein kinase 2, alpha 1 polypeptide
casein kinase 2, alpha 1 polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101266:
This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012] Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:152226839-152281852
Strand Forward strand
Band G3
Transcripts
ENSMUST00000099224 ENSMUSP00000096829
ENSMUST00000136063
ENSMUST00000124791 ENSMUSP00000122505
ENSMUST00000133119 ENSMUSP00000116853
ENSMUST00000141597
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 315 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 315 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008013 beta-catenin binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019888 protein phosphatase regulator activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0008284 positive regulation of cell proliferation
GO:0016055 Wnt signaling pathway
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030307 positive regulation of cell growth
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045732 positive regulation of protein catabolic process
GO:0046777 protein autophosphorylation
GO:0048511 rhythmic process
GO:0050790 regulation of catalytic activity
GO:0071174 mitotic spindle checkpoint
Cellular Component
GO:0005956 protein kinase CK2 complex
GO:0031519 PcG protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Cell Cycle, Mitotic pathway
Disease pathway
Signaling by Wnt pathway
Signaling by WNT in cancer pathway
Cell Cycle pathway
M Phase pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF dependent signaling in response to WNT pathway
Mitotic Prometaphase pathway
Axon guidance pathway
Signal transduction by L1 pathway
Condensation of Prometaphase Chromosomes pathway
L1CAM interactions pathway
Developmental Biology pathway
Signal Transduction pathway
WNT mediated activation of DVL pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
Wnt signaling pathway pathway
Adherens junction pathway
Tight junction pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
Leptin pathway
REACTOME
Developmental Biology pathway
WNT mediated activation of DVL pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Axon guidance pathway
Signal Transduction pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
Condensation of Prometaphase Chromosomes pathway
M Phase pathway
TCF dependent signaling in response to WNT pathway
L1CAM interactions pathway
Signal transduction by L1 pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
Adherens junction pathway
Tight junction pathway
INOH
PID BIOCARTA
Segmentation clock [Biocarta view]
Lissencephaly gene (lis1) in neuronal migration and development [Biocarta view]
Inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages [Biocarta view]
Bcr signaling pathway [Biocarta view]
Pdgf signaling pathway [Biocarta view]
Nerve growth factor pathway (ngf) [Biocarta view]
Calcium signaling by hbx of hepatitis b virus [Biocarta view]
Tpo signaling pathway [Biocarta view]
Multi-step regulation of transcription by pitx2 [Biocarta view]
Igf-1 signaling pathway [Biocarta view]
Wnt signaling pathway [Biocarta view]
PID NCI
Alpha-synuclein signaling
Presenilin action in Notch and Wnt signaling
BCR signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Lissencephaly gene (LIS1) in neuronal migration and development
PDGFR-alpha signaling pathway
Cross-References
SwissProt Q60737
TrEMBL Q6NSS6
UniProt Splice Variant
Entrez Gene 12995
UniGene Mm.23692 Mm.401524 Mm.406307 Mm.409916 Mm.431633
RefSeq NM_007788 XM_006498657
OMIM
CCDS CCDS16879
HPRD
IMGT
MGI ID MGI:88543
MGI Symbol Csnk2a1
EMBL AK146032 AK158077 AL831735 BC026149 BC060742 BC069919 BC089343 CH466551 U17112
GenPept AAA64563 AAH26149 AAH60742 AAH69919 AAH89343 BAE26845 BAE34350 CAM24731 EDL05953
RNA Seq Atlas 12995