Version 5.4
Mus musculus Gene: Defb21
Summary
InnateDB Gene IDBG-209787.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Defb21
Gene Name defensin beta 21
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000056544
Encoded Proteins
IDBP-209789
defensin beta 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131068:
This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. Expression of this gene is regulated by androgen, and the encoded protein binds to sperm and exhibits antibacterial activity. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:152572744-152574944
Strand Forward strand
Band H1
Transcripts
ENSMUST00000070722 ENSMUSP00000065102
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
GO:0042742 defense response to bacterium
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000131068
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_115897
Beta defensins pathway
REACT_115846
Defensins pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q2F9P8 Q8C5Z4
UniProt Splice Variant
Entrez Gene 403172
UniGene Mm.84518
RefSeq NM_207276 XM_006499851
OMIM
CCDS CCDS16890
HPRD
IMGT
MGI ID MGI:2684967
MGI Symbol Defb21
EMBL AK076875 AL845162 DQ012032 DQ141308
GenPept AAY59768 ABA26844 BAC36517
RNA Seq Atlas 403172

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca