Version 5.4
Mus musculus Gene: H13
Summary
InnateDB Gene IDBG-209822.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H13
Gene Name histocompatibility 13
Synonyms 1200006O09Rik; 4930443L17Rik; 5031424B04Rik; AV020344; H-13; Hm13; PSL3; Spp
Species Mus musculus
Ensembl Gene ENSMUSG00000019188
Encoded Proteins
IDBP-209824
histocompatibility 13
IDBP-209826
histocompatibility 13
IDBP-261560
histocompatibility 13
IDBP-539615
histocompatibility 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101294:
The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:152669461-152708670
Strand Forward strand
Band H1
Transcripts
ENSMUST00000089059 ENSMUSP00000086460
ENSMUST00000079247 ENSMUSP00000078236
ENSMUST00000109825 ENSMUSP00000105450
ENSMUST00000125366 ENSMUSP00000120068
ENSMUST00000148156
ENSMUST00000129439
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004190 aspartic-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0042500 aspartic endopeptidase activity, intramembrane cleaving
GO:0042803 protein homodimerization activity
Biological Process
GO:0006508 proteolysis
GO:0033619 membrane protein proteolysis
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005791 rough endoplasmic reticulum
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101294
View Gene Order
ENSBTAG00000008840
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001159551 NM_001159552 NM_010376
OMIM
CCDS CCDS16896 CCDS50752 CCDS50753
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca