InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Foxs1

Summary

InnateDB Gene

IDBG-209923.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxs1

Gene Name

forkhead box S1

Synonyms

Fkh3; Fkhl18; FREAC10

Species

Mus musculus

Ensembl Gene

ENSMUSG00000074676

Encoded Proteins

IDBP-209925

forkhead box S1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179772:
The forkhead family of transcription factors belongs to the winged helix class of DNA-binding proteins. The protein encoded by this intronless gene contains a forkhead domain and is found predominantly in aorta and kidney. The function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:152931898-152933208

Strand

Reverse strand

Band

Transcripts

ENSMUST00000099200

ENSMUSP00000096806

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001503	ossification
GO:0001568	blood vessel development
GO:0001569	patterning of blood vessels
GO:0001756	somitogenesis
GO:0001946	lymphangiogenesis
GO:0001974	blood vessel remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007219	Notch signaling pathway
GO:0008286	insulin receptor signaling pathway
GO:0030199	collagen fibril organization
GO:0035050	embryonic heart tube development
GO:0040018	positive regulation of multicellular organism growth
GO:0043010	camera-type eye development
GO:0043066	negative regulation of apoptotic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046620	regulation of organ growth
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048343	paraxial mesodermal cell fate commitment
GO:0048844	artery morphogenesis
GO:0050880	regulation of blood vessel size
GO:0050885	neuromuscular process controlling balance
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060038	cardiac muscle cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000179772

View Gene Order

ENSBTAG00000009206

Not yet available

Cross-References

SwissProt

Q61574

TrEMBL

Q4VA05

UniProt Splice Variant

Entrez Gene

14239

UniGene

Mm.205798

RefSeq

NM_010226

OMIM

CCDS

CCDS16901

HPRD

IMGT

MGI ID

MGI:95546

MGI Symbol

Foxs1

EMBL

AK077935 AK152669 BC096604 BC131937 BC131939 X71941

GenPept

AAH96604 AAI31938 AAI31940 BAC37074 BAE31404 CAA50743

RNA Seq Atlas

14239