|Mus musculus Gene: Asxl1|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||additional sex combs like 1|
additional sex combs like 1 (Drosophila)
|Useful resources||Stemformatics EHFPI ImmGen|
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171456:
This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
|Genomic Location||Chromosome 2:153345845-153404007|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Not yet available
|UniProt Splice Variant|
|UniGene||Mm.330677 Mm.350418 Mm.392996 Mm.453694|
|RNA Seq Atlas||228790|