InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Asxl1

Summary

InnateDB Protein

IDBP-261646.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Asxl1

Protein Name

additional sex combs like 1 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105413

InnateDB Gene

IDBG-210087 (Asxl1)

Protein Structure

UniProt Annotation

Function

Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as a coactivator of RARA and RXRA through association with NCOA1. Acts as a corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters. Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). {ECO:0000269PubMed:16606617, ECO:0000269PubMed:19880879, ECO:0000269PubMed:21047783}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19880879}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042974	retinoic acid receptor binding
GO:0042975	peroxisome proliferator activated receptor binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0032526	response to retinoic acid
GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035522	monoubiquitinated histone H2A deubiquitination
GO:0045599	negative regulation of fat cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048386	positive regulation of retinoic acid receptor signaling pathway
GO:0048387	negative regulation of retinoic acid receptor signaling pathway
GO:0060348	bone development