Version 5.4
Mus musculus Gene: Dmbt1
Summary
InnateDB Gene IDBG-210881.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dmbt1
Gene Name deleted in malignant brain tumors 1
Synonyms CRP; CRP-[a]; CRP-[b]; Crpd; DBMT1; gp300; p80
Species Mus musculus
Ensembl Gene ENSMUSG00000047517
Encoded Proteins
IDBP-210883
deleted in malignant brain tumors 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20418254
[Homo sapiens] DMBT1 encodes alternatively spliced proteins involved in mucosal innate immunity and two other molecules, a glycoprotein with a molecular mass of 340 kDa (GP340) and salivary agglutinin (DMBT1(SAG)). GP340 is secreted into broncho-alveolar surface lining fluid whereas DMBT1(SAG) is present in the saliva. Both interact with and agglutinate several Gram-negative and Gram-positive bacteria, as well as some viruses.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187908:
Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Jul 2008]
Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:131032076-131121626
Strand Forward strand
Band F3
Transcripts
ENSMUST00000084509 ENSMUSP00000081556
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
Biological Process
GO:0001824 blastocyst development
GO:0001833 inner cell mass cell proliferation
GO:0006898 receptor-mediated endocytosis
GO:0030858 positive regulation of epithelial cell differentiation
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030670 phagocytic vesicle membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000187908
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04970
Salivary secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04970
Salivary secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9QPG8 Q9JHU8
UniProt Splice Variant
Entrez Gene 12945
UniGene
RefSeq NM_007769 XM_006507298 XM_006507300 XM_006507301 XM_006507303
OMIM
CCDS CCDS21909
HPRD
IMGT
MGI ID MGI:106210
MGI Symbol Dmbt1
EMBL AC087063 AY004216
GenPept AAF93167
RNA Seq Atlas 12945

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca