Version 5.4
Homo sapiens Gene: RFX2
Summary
InnateDB Gene IDBG-21095.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RFX2
Gene Name regulatory factor X, 2 (influences HLA class II expression)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000087903
Encoded Proteins
IDBP-21097
regulatory factor X, 2 (influences HLA class II expression)
IDBP-21099
regulatory factor X, 2 (influences HLA class II expression)
IDBP-759953
IDBP-764997
IDBP-763222
IDBP-765051
IDBP-766279
IDBP-765058
IDBP-760582
IDBP-764685
IDBP-765959
IDBP-763304
IDBP-759817
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:5993164-6199572
Strand Reverse strand
Band p13.3
Transcripts
ENST00000303657 ENSP00000306335
ENST00000359161 ENSP00000352076
ENST00000592281 ENSP00000468561
ENST00000592337
ENST00000593241 ENSP00000466890
ENST00000586302 ENSP00000467979
ENST00000587181 ENSP00000465135
ENST00000589340 ENSP00000466028
ENST00000586806 ENSP00000467736
ENST00000586940
ENST00000589523
ENST00000590778
ENST00000587321 ENSP00000465122
ENST00000592883 ENSP00000464826
ENST00000585324
ENST00000592546 ENSP00000467166
ENST00000590822
ENST00000587700
ENST00000592172
ENST00000589742 ENSP00000466177
ENST00000589641
ENST00000589712
ENST00000592473 ENSP00000468036
ENST00000588021
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024206
View Gene Order
ENSBTAG00000017661
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.465709 Hs.624636 Hs.659115 Hs.677653
RefSeq NM_000635 NM_134433
HUGO
OMIM
CCDS CCDS12157 CCDS12158
HPRD 00824
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca