Mus musculus Gene: Acly | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-211434.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Acly | ||||||||||||||||||||||
Gene Name | ATP citrate lyase | ||||||||||||||||||||||
Synonyms | A730098H14Rik; AW538652 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000020917 | ||||||||||||||||||||||
Encoded Proteins |
ATP citrate lyase
ATP citrate lyase
ATP citrate lyase
ATP citrate lyase
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131473:
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 11:100476353-100528000 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | D | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Integration of energy metabolism pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
ChREBP activates metabolic gene expression pathway
Fatty Acyl-CoA Biosynthesis pathway
Triglyceride Biosynthesis pathway
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KEGG |
Citrate cycle (TCA cycle) pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
TCR pathway
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REACTOME |
Fatty Acyl-CoA Biosynthesis pathway
Triglyceride Biosynthesis pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
ChREBP activates metabolic gene expression pathway
Integration of energy metabolism pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
Integration of energy metabolism pathway
Metabolism of lipids and lipoproteins pathway
Triglyceride Biosynthesis pathway
Metabolism pathway
ChREBP activates metabolic gene expression pathway
Fatty Acyl-CoA Biosynthesis pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
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KEGG |
Citrate cycle (TCA cycle) pathway
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INOH |
Citrate cycle pathway
Lysine degradation pathway
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PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.282039 | ||||||||||||||||||||||
RefSeq | NM_001199296 NM_134037 XM_006531934 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS25425 CCDS56807 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||