InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACLY

Summary

InnateDB Gene

IDBG-49990.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACLY

Gene Name

ATP citrate lyase

Synonyms

ACL; ATPCL; CLATP

Species

Homo sapiens

Ensembl Gene

ENSG00000131473

Encoded Proteins

IDBP-49992

ATP citrate lyase

IDBP-49994

ATP citrate lyase

IDBP-242679

ATP citrate lyase

IDBP-594819

ATP citrate lyase

IDBP-761591

IDBP-764954

IDBP-762445

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:41866908-41930542

Strand

Reverse strand

Band

q21.2

Transcripts

ENST00000352035	ENSP00000253792
ENST00000353196	ENSP00000345398
ENST00000393896	ENSP00000377474
ENST00000537919	ENSP00000445349
ENST00000592970	ENSP00000468705
ENST00000590770	ENSP00000464717
ENST00000588779
ENST00000590151	ENSP00000466259
ENST00000590735
ENST00000588547

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	44 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003878	ATP citrate synthase activity
GO:0004775	succinate-CoA ligase (ADP-forming) activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046872	metal ion binding
GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
GO:0048037	cofactor binding

Biological Process

GO:0006101	citrate metabolic process
GO:0006112	energy reserve metabolic process
GO:0006200	ATP catabolic process
GO:0008152	metabolic process
GO:0008610	lipid biosynthetic process
GO:0015936	coenzyme A metabolic process
GO:0019432	triglyceride biosynthetic process
GO:0031325	positive regulation of cellular metabolic process
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044262	cellular carbohydrate metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0009346	citrate lyase complex
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome