InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBE2V2

Summary

InnateDB Gene

IDBG-21151.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2V2

Gene Name

ubiquitin-conjugating enzyme E2 variant 2

Synonyms

DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1; MMS2; UEV-2; UEV2

Species

Homo sapiens

Ensembl Gene

ENSG00000169139

Encoded Proteins

IDBP-481344

ubiquitin-conjugating enzyme E2 variant 2

IDBP-483818

ubiquitin-conjugating enzyme E2 variant 2

IDBP-481275

ubiquitin-conjugating enzyme E2 variant 2

IDBP-483067

ubiquitin-conjugating enzyme E2 variant 2

IDBP-480364

ubiquitin-conjugating enzyme E2 variant 2

IDBP-475267

ubiquitin-conjugating enzyme E2 variant 2

IDBP-478658

ubiquitin-conjugating enzyme E2 variant 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26101372

TRIM5 requires UBE2W, UBE2N and UBE2V2 enzymatic activities to inhibit retroviral DNA synthesis

Entrez Gene

Summary

Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:48008400-48064708

Strand

Forward strand

Band

q11.21

Transcripts

ENST00000523111	ENSP00000428209
ENST00000523432	ENSP00000430019
ENST00000521346	ENSP00000428818
ENST00000518360	ENSP00000430491
ENST00000517630	ENSP00000429886
ENST00000520809	ENSP00000429419
ENST00000520595	ENSP00000430741
ENST00000521628

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.

Experimentally validated
Total	61 [view]
Protein-Protein	61 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0000729	DNA double-strand break processing
GO:0006282	regulation of DNA repair
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0010976	positive regulation of neuron projection development
GO:0016567	protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045739	positive regulation of DNA repair
GO:0051965	positive regulation of synapse assembly

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0031372	UBC13-MMS2 complex
GO:0070062	extracellular vesicular exosome

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.491695 Hs.705912 Hs.740739

RefSeq

NM_003350 XM_005251300

HUGO

OMIM

CCDS

CCDS43738

HPRD

04300

IMGT

EMBL

GenPept

RNA Seq Atlas