Homo sapiens Gene: UBE2V2
Summary
InnateDB Gene IDBG-21151.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2V2
Gene Name ubiquitin-conjugating enzyme E2 variant 2
Synonyms DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1; MMS2; UEV-2; UEV2;
Species Homo sapiens
Ensembl Gene ENSG00000169139
Encoded Proteins
ubiquitin-conjugating enzyme E2 variant 2
ubiquitin-conjugating enzyme E2 variant 2
ubiquitin-conjugating enzyme E2 variant 2
ubiquitin-conjugating enzyme E2 variant 2
ubiquitin-conjugating enzyme E2 variant 2
ubiquitin-conjugating enzyme E2 variant 2
ubiquitin-conjugating enzyme E2 variant 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
TRIM5 requires UBE2W, UBE2N and UBE2V2 enzymatic activities to inhibit retroviral DNA synthesis
Entrez Gene
Summary Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:48008400-48064708
Strand Forward strand
Band q11.21
Transcripts
ENST00000523111 ENSP00000428209
ENST00000523432 ENSP00000430019
ENST00000521346 ENSP00000428818
ENST00000518360 ENSP00000430491
ENST00000517630 ENSP00000429886
ENST00000520809 ENSP00000429419
ENST00000520595 ENSP00000430741
ENST00000521628
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
Experimentally validated
Total 61 [view]
Protein-Protein 61 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0000729 DNA double-strand break processing
GO:0006282 regulation of DNA repair
GO:0008152 metabolic process
GO:0008283 cell proliferation
GO:0010976 positive regulation of neuron projection development
GO:0016567 protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045739 positive regulation of DNA repair
GO:0051965 positive regulation of synapse assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031372 UBC13-MMS2 complex
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.491695 Hs.705912 Hs.740739
RefSeq NM_003350 XM_005251300
HUGO
OMIM
CCDS CCDS43738
HPRD 04300
IMGT
EMBL
GenPept
RNA Seq Atlas