InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2V2

Summary

InnateDB Protein

IDBP-481344.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2V2

Protein Name

ubiquitin-conjugating enzyme E2 variant 2

Synonyms

DDVit-1; DDVIT1; EDAF-1; EDPF-1; EDPF1; MMS2; UEV-2; UEV2;

Species

Homo sapiens

Ensembl Protein

ENSP00000428209

InnateDB Gene

IDBG-21151 (UBE2V2)

Protein Structure

UniProt Annotation

Function

Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. {ECO:0000269PubMed:10089880, ECO:0000269PubMed:14562038, ECO:0000269PubMed:20061386, ECO:0000269PubMed:9705497}.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues. {ECO:0000269PubMed:9199207, ECO:0000269PubMed:9705497}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.

Experimentally validated
Total	61 [view]
Protein-Protein	61 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0000729	DNA double-strand break processing
GO:0006282	regulation of DNA repair
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0010976	positive regulation of neuron projection development
GO:0016567	protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045739	positive regulation of DNA repair
GO:0051965	positive regulation of synapse assembly