Version 5.4
| Mus musculus Gene: Plcg1 | |||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-211621.6 | ||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||
| Gene Symbol | Plcg1 | ||||||||||||||||||||||||||||||
| Gene Name | phospholipase C, gamma 1 | ||||||||||||||||||||||||||||||
| Synonyms | AI894140; Cded; Plc-1; Plc-gamma1; Plcg-1 | ||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000016933 | ||||||||||||||||||||||||||||||
| Encoded Proteins |
phospholipase C, gamma 1
phospholipase C, gamma 1
phospholipase C, gamma 1
phospholipase C, gamma 1
phospholipase C, gamma 1
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| Protein Structure | |||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124181:
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 2:160731300-160775760 | ||||||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||||||
| Band | H2 | ||||||||||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 154 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||
| REACTOME |
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PLCG1 events in ERBB2 signaling pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
Disease pathway
Signaling by constitutively active EGFR pathway
Role of phospholipids in phagocytosis pathway
Netrin-1 signaling pathway
Signaling by VEGF pathway
Signaling by FGFR in disease pathway
Cytokine Signaling in Immune system pathway
VEGFR2 mediated cell proliferation pathway
PLC-gamma1 signalling pathway
Antiviral mechanism by IFN-stimulated genes pathway
ISG15 antiviral mechanism pathway
Metabolism pathway
Immune System pathway
EGFR interacts with phospholipase C-gamma pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Role of second messengers in netrin-1 signaling pathway
Signaling by EGFR pathway
Frs2-mediated activation pathway
Interferon Signaling pathway
Phospholipase C-mediated cascade pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
FCERI mediated Ca+2 mobilization pathway
Signalling to ERKs pathway
Signaling by FGFR mutants pathway
Signaling by FGFR1 mutants pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
Developmental Biology pathway
DAG and IP3 signaling pathway
Signaling by FGFR1 fusion mutants pathway
NGF signalling via TRKA from the plasma membrane pathway
Signal Transduction pathway
Inositol phosphate metabolism pathway
Synthesis of IP3 and IP4 in the cytosol pathway
Prolonged ERK activation events pathway
Signaling by FGFR pathway
Generation of second messenger molecules pathway
FCERI mediated MAPK activation pathway
TCR signaling pathway
Signaling by EGFR in Cancer pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
ErbB signaling pathway pathway
VEGF signaling pathway pathway
Calcium signaling pathway pathway
T cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Phosphatidylinositol signaling system pathway
Glioma pathway
Leukocyte transendothelial migration pathway
Inositol phosphate metabolism pathway
Non-small cell lung cancer pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
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| INOH |
CD4 T cell receptor signaling pathway
FGF signaling pathway pathway
VEGF signaling pathway pathway
HGF signaling pathway pathway
NGF signaling pathway pathway
PDGF signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
KitReceptor pathway
TCR pathway
BCR pathway
IL1 pathway
IL4 pathway
IL6 pathway
RANKL pathway
Leptin pathway
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| REACTOME |
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Role of phospholipids in phagocytosis pathway
Generation of second messenger molecules pathway
ISG15 antiviral mechanism pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
PECAM1 interactions pathway
Cell surface interactions at the vascular wall pathway
PLC-gamma1 signalling pathway
Frs2-mediated activation pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Synthesis of IP3 and IP4 in the cytosol pathway
Signaling by constitutively active EGFR pathway
Signaling by FGFR1 fusion mutants pathway
Signaling by FGFR mutants pathway
Role of second messengers in netrin-1 signaling pathway
Netrin-1 signaling pathway
Signaling by FGFR in disease pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
TCR signaling pathway
Antiviral mechanism by IFN-stimulated genes pathway
Signaling by VEGF pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Signaling by FGFR1 mutants pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Interferon Signaling pathway
Adaptive Immune System pathway
Immune System pathway
VEGFR2 mediated cell proliferation pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Prolonged ERK activation events pathway
Inositol phosphate metabolism pathway
Metabolism pathway
FCERI mediated Ca+2 mobilization pathway
Signaling by the B Cell Receptor (BCR) pathway
Disease pathway
FCERI mediated MAPK activation pathway
Hemostasis pathway
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| KEGG |
Vibrio cholerae infection pathway
VEGF signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Non-small cell lung cancer pathway
Inositol phosphate metabolism pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
ErbB signaling pathway pathway
Leukocyte transendothelial migration pathway
Glioma pathway
Phosphatidylinositol signaling system pathway
T cell receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Calcium signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
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| INOH |
CD4 T cell receptor signaling pathway
FGF signaling pathway pathway
VEGF signaling pathway pathway
HGF signaling pathway pathway
NGF signaling pathway pathway
Inositol phosphate metabolism pathway
PDGF signaling pathway pathway
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| PID NCI |
Trk receptor signaling mediated by PI3K and PLC-gamma
Nephrin/Neph1 signaling in the kidney podocyte
EPHA forward signaling
TCR signaling in naïve CD8+ T cells
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
S1P1 pathway
LPA receptor mediated events
Netrin-mediated signaling events
TCR signaling in naïve CD4+ T cells
Signaling events mediated by focal adhesion kinase
EPO signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
FGF signaling pathway
S1P4 pathway
Signaling events mediated by VEGFR1 and VEGFR2
Regulation of CDC42 activity
Fc-epsilon receptor I signaling in mast cells
VEGFR1 specific signals
E-cadherin signaling in keratinocytes
PDGFR-alpha signaling pathway
PDGFR-beta signaling pathway
N-cadherin signaling events
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| Cross-References | |||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||
| UniGene | Mm.44463 Mm.474234 Mm.486517 | ||||||||||||||||||||||||||||||
| RefSeq | NM_021280 | ||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||
| CCDS | CCDS16996 | ||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||