Mus musculus Gene: Plcg1
Summary
InnateDB Gene IDBG-211621.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plcg1
Gene Name phospholipase C, gamma 1
Synonyms AI894140; Cded; Plc-1; Plc-gamma1; Plcg-1;
Species Mus musculus
Ensembl Gene ENSMUSG00000016933
Encoded Proteins
phospholipase C, gamma 1
phospholipase C, gamma 1
phospholipase C, gamma 1
phospholipase C, gamma 1
phospholipase C, gamma 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124181:
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:160731300-160775760
Strand Forward strand
Band H2
Transcripts
ENSMUST00000103115 ENSMUSP00000099404
ENSMUST00000017077
ENSMUST00000109462 ENSMUSP00000105088
ENSMUST00000151590 ENSMUSP00000133771
ENSMUST00000129568
ENSMUST00000124652
ENSMUST00000147254
ENSMUST00000143997 ENSMUSP00000115181
ENSMUST00000174885 ENSMUSP00000134720
ENSMUST00000173791
ENSMUST00000173335
ENSMUST00000173061
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 154 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 154 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004871 signal transducer activity
GO:0005168 neurotrophin TRKA receptor binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
GO:0019901 protein kinase binding
GO:0030971 receptor tyrosine kinase binding
GO:0035254 glutamate receptor binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008152 metabolic process
GO:0009395 phospholipid catabolic process
GO:0010634 positive regulation of epithelial cell migration
GO:0016477 cell migration
GO:0019722 calcium-mediated signaling
GO:0035556 intracellular signal transduction
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0050852 T cell receptor signaling pathway
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0071364 cellular response to epidermal growth factor stimulus
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0008180 COP9 signalosome
GO:0030027 lamellipodium
GO:0042995 cell projection
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PLCG1 events in ERBB2 signaling pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
Disease pathway
Signaling by constitutively active EGFR pathway
Role of phospholipids in phagocytosis pathway
Netrin-1 signaling pathway
Signaling by VEGF pathway
Signaling by FGFR in disease pathway
Cytokine Signaling in Immune system pathway
VEGFR2 mediated cell proliferation pathway
PLC-gamma1 signalling pathway
Antiviral mechanism by IFN-stimulated genes pathway
ISG15 antiviral mechanism pathway
Metabolism pathway
Immune System pathway
EGFR interacts with phospholipase C-gamma pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Role of second messengers in netrin-1 signaling pathway
Signaling by EGFR pathway
Frs2-mediated activation pathway
Interferon Signaling pathway
Phospholipase C-mediated cascade pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
FCERI mediated Ca+2 mobilization pathway
Signalling to ERKs pathway
Signaling by FGFR mutants pathway
Signaling by FGFR1 mutants pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
Developmental Biology pathway
DAG and IP3 signaling pathway
Signaling by FGFR1 fusion mutants pathway
NGF signalling via TRKA from the plasma membrane pathway
Signal Transduction pathway
Inositol phosphate metabolism pathway
Synthesis of IP3 and IP4 in the cytosol pathway
Prolonged ERK activation events pathway
Signaling by FGFR pathway
Generation of second messenger molecules pathway
FCERI mediated MAPK activation pathway
TCR signaling pathway
Signaling by EGFR in Cancer pathway
DAP12 interactions pathway
DAP12 signaling pathway
KEGG
Inositol phosphate metabolism pathway
ErbB signaling pathway pathway
Calcium signaling pathway pathway
Phosphatidylinositol signaling system pathway
VEGF signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Leukocyte transendothelial migration pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
Glioma pathway
Non-small cell lung cancer pathway
INOH
NGF signaling pathway pathway
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
FGF signaling pathway pathway
VEGF signaling pathway pathway
HGF signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
KitReceptor pathway
TCR pathway
BCR pathway
IL1 pathway
IL4 pathway
IL6 pathway
RANKL pathway
Leptin pathway
REACTOME
Signaling by FGFR in disease pathway
Signaling by FGFR mutants pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Phospholipase C-mediated cascade pathway
PECAM1 interactions pathway
TCR signaling pathway
DAP12 signaling pathway
Antiviral mechanism by IFN-stimulated genes pathway
Signaling by constitutively active EGFR pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Signaling by FGFR1 mutants pathway
Role of phospholipids in phagocytosis pathway
Frs2-mediated activation pathway
PLC-gamma1 signalling pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
DAG and IP3 signaling pathway
Signal Transduction pathway
Interferon Signaling pathway
Netrin-1 signaling pathway
Adaptive Immune System pathway
Immune System pathway
Role of second messengers in netrin-1 signaling pathway
Downstream signal transduction pathway
VEGFR2 mediated cell proliferation pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Prolonged ERK activation events pathway
Signaling by FGFR pathway
ISG15 antiviral mechanism pathway
Inositol phosphate metabolism pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Metabolism pathway
Generation of second messenger molecules pathway
FCERI mediated Ca+2 mobilization pathway
Signaling by the B Cell Receptor (BCR) pathway
PLCG1 events in ERBB2 signaling pathway
Cell surface interactions at the vascular wall pathway
Signaling by FGFR1 fusion mutants pathway
Disease pathway
FCERI mediated MAPK activation pathway
Hemostasis pathway
DAP12 interactions pathway
Synthesis of IP3 and IP4 in the cytosol pathway
EGFR interacts with phospholipase C-gamma pathway
KEGG
Inositol phosphate metabolism pathway
ErbB signaling pathway pathway
Calcium signaling pathway pathway
Phosphatidylinositol signaling system pathway
VEGF signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Leukocyte transendothelial migration pathway
Neurotrophin signaling pathway pathway
Vibrio cholerae infection pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Pathways in cancer pathway
Glioma pathway
Non-small cell lung cancer pathway
INOH
NGF signaling pathway pathway
Inositol phosphate metabolism pathway
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
FGF signaling pathway pathway
VEGF signaling pathway pathway
HGF signaling pathway pathway
PID BIOCARTA
Signaling pathway from g-protein families [Biocarta view]
Ionomycin and phorbal ester signaling pathway [Biocarta view]
Vegf hypoxia and angiogenesis [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Cxcr4 signaling pathway [Biocarta view]
Actions of nitric oxide in the heart [Biocarta view]
Epo signaling pathway [Biocarta view]
Bcr signaling pathway [Biocarta view]
Trka receptor signaling pathway [Biocarta view]
Phospholipase c signaling pathway [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
Effects of calcineurin in keratinocyte differentiation [Biocarta view]
Pertussis toxin-insensitive ccr5 signaling in macrophage [Biocarta view]
Pdgf signaling pathway [Biocarta view]
Role of mef2d in t-cell apoptosis [Biocarta view]
Nerve growth factor pathway (ngf) [Biocarta view]
Growth hormone signaling pathway [Biocarta view]
Tpo signaling pathway [Biocarta view]
Erk and pi-3 kinase are necessary for collagen binding in corneal epithelia [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
Role of erk5 in neuronal survival pathway [Biocarta view]
Links between pyk2 and map kinases [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Egf signaling pathway [Biocarta view]
Phosphoinositides and their downstream targets [Biocarta view]
Fc epsilon receptor i signaling in mast cells [Biocarta view]
PID NCI
Trk receptor signaling mediated by PI3K and PLC-gamma
Nephrin/Neph1 signaling in the kidney podocyte
EPHA forward signaling
TCR signaling in na´ve CD8+ T cells
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
S1P1 pathway
LPA receptor mediated events
Netrin-mediated signaling events
TCR signaling in na´ve CD4+ T cells
Signaling events mediated by focal adhesion kinase
EPO signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
FGF signaling pathway
S1P4 pathway
Signaling events mediated by VEGFR1 and VEGFR2
Regulation of CDC42 activity
Fc-epsilon receptor I signaling in mast cells
VEGFR1 specific signals
E-cadherin signaling in keratinocytes
PDGFR-alpha signaling pathway
PDGFR-beta signaling pathway
N-cadherin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 18803
UniGene Mm.44463 Mm.474234 Mm.486517
RefSeq NM_021280
OMIM
CCDS CCDS16996
HPRD
IMGT
MGI ID MGI:97615
MGI Symbol Plcg1
EMBL
GenPept
RNA Seq Atlas 18803