InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mlx

Summary

InnateDB Gene

IDBG-211822.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mlx

Gene Name

MAX-like protein X

Synonyms

bHLHd13; Tcfl4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000017801

Encoded Proteins

IDBP-211824

MAX-like protein X

IDBP-266949

MAX-like protein X

IDBP-266951

MAX-like protein X

IDBP-536617

MAX-like protein X

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108788:
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:101087277-101092207

Strand

Forward strand

Band

Transcripts

ENSMUST00000017945	ENSMUSP00000017945
ENSMUST00000107303	ENSMUSP00000102924
ENSMUST00000107302	ENSMUSP00000102923
ENSMUST00000149411
ENSMUST00000145187
ENSMUST00000149597	ENSMUSP00000121600
ENSMUST00000143344

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0008134	transcription factor binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006913	nucleocytoplasmic transport
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000108788

View Gene Order

ENSBTAG00000046670

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_2122

ChREBP activates metabolic gene expression pathway

REACT_1505

Integration of energy metabolism pathway

REACT_111217

Metabolism pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.628

RefSeq

NM_001159384 NM_001159385 NM_011550 XM_006532809

OMIM

CCDS

CCDS25447 CCDS48935 CCDS48936

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas