Homo sapiens Gene: MLX
Summary
InnateDB Gene IDBG-51109.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MLX
Gene Name MLX, MAX dimerization protein
Synonyms bHLHd13; MAD7; MXD7; TCFL4;
Species Homo sapiens
Ensembl Gene ENSG00000108788
Encoded Proteins
MAX-like protein X
MAX-like protein X
MAX-like protein X
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42567068-42573239
Strand Forward strand
Band q21.2
Transcripts
ENST00000246912 ENSP00000246912
ENST00000346833 ENSP00000320913
ENST00000435881 ENSP00000416627
ENST00000591195
ENST00000592717
ENST00000585403
ENST00000590050
ENST00000590084
ENST00000586393
ENST00000588320
ENST00000591024 ENSP00000464697
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008134 transcription factor binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006112 energy reserve metabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006913 nucleocytoplasmic transport
GO:0031325 positive regulation of cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Integration of energy metabolism pathway
ChREBP activates metabolic gene expression pathway
Metabolism pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.714749 Hs.732454
RefSeq NM_170607 NM_198204 NM_198205
HUGO
OMIM
CCDS CCDS11430 CCDS42341 CCDS45687
HPRD 04278
IMGT
EMBL
GenPept
RNA Seq Atlas